Natural cytotoxicity triggering receptor 3 (Activating natural killer receptor p30) (Natural killer cell p30-related protein) (NK-p30) (NKp30) (CD antigen CD337)
1_MAWML 6_ LLILI 11_ MVHPG 16_ SCALW 21_ VSQPP 26_ EIRTL 31_ EGSSA 36_ FLPCS 41_ FNASQ 46_ GRLAI 51_ GSVTW 56_ FRDEV 61_ VPGKE 66_ VRNGT 71_ PEFRG 76_ RLAPL 81_ ASSRF 86_ LHDHQ 91_ AELHI 96_ RDVRG 101_ HDASI 106_ YVCRV 111_ EVLGL 116_ GVGTG 121_ NGTRL 126_ VVEKE 131_ HPQLG 136_ AGTVL 141_ LLRAG 146_ FYAVS 151_ FLSVA 156_ VGSTV 161_ YYQGK 166_ CLTWK 171_ GPRRQ 176_ LPAVV 181_ PAPLP 186_ PPCGS 191_ SAHLL 196_PPVPG
1: Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation