Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
1_MADDD 6_ VLFED 11_ VYELC 16_ EVIGK 21_ GPFSV 26_ VRRCI 31_ NRETG 36_ QQFAV 41_ KIVDV 46_ AKFTS 51_ SPGLS 56_ TEDLK 61_ REASI 66_ CHMLK 71_ HPHIV 76_ ELLET 81_ YSSDG 86_ MLYMV 91_ FEFMD 96_ GADLC 101_ FEIVK 106_ RADAG 111_ FVYSE 116_ AVASH 121_ YMRQI 126_ LEALR 131_ YCHDN 136_ NIIHR 141_ DVKPH 146_ CVLLA 151_ SKENS 156_ APVKL 161_ GGFGV 166_ AIQLG 171_ ESGLV 176_ AGGRV 181_ GTPHF 186_ MAPEV 191_ VKREP 196_ YGKPV 201_ DVWGC 206_ GVILF 211_ ILLSG 216_ CLPFY 221_ GTKER 226_ LFEGI 231_ IKGKY 236_ KMNPR 241_ QWSHI 246_ SESAK 251_ DLVRR 256_ MLMLD 261_ PAERI 266_ TVYEA 271_ LNHPW 276_ LKERD 281_ RYAYK 286_ IHLPE 291_ TVEQL 296_ RKFNA 301_ RRKLK 306_ GAVLA 311_ AVSSH 316_ KFNSF 321_ YGDPP 326_ EELPD 331_ FSEDP 336_ TSSGL 341_ LAAER 346_ AVSQV 351_ LDSLE 356_ EIHAL 361_ TDCSE 366_ KDLDF 371_ LHSVF 376_ QDQHL 381_ HTLLD 386_ LYDKI 391_ NTKSS 396_ PQIRN 401_ PPSDA 406_ VQRAK 411_ EVLEE 416_ ISCYP 421_ ENNDA 426_ KELKR 431_ ILTQP 436_ HFMAL 441_ LQTHD 446_ VVAHE 451_ VYSDE 456_ ALRVT 461_ PPPTS 466_ PYLNG 471_ DSPES 476_ ANGDM 481_ DMENV 486_ TRVRL 491_ VQFQK 496_ NTDEP 501_ MGITL 506_ KMNEL 511_ NHCIV 516_ ARIMH 521_ GGMIH 526_ RQGTL 531_ HVGDE 536_ IREIN 541_ GISVA 546_ NQTVE 551_ QLQKM 556_ LREMR 561_ GSITF 566_ KIVPS 571_ YRTQS 576_ SSCER 581_ DSPST 586_ SRQSP 591_ ANGHS 596_ STNNS 601_ VSDLP 606_ STTQP 611_ KGRQI 616_ YVRAQ 621_ FEYDP 626_ AKDDL 631_ IPCKE 636_ AGIRF 641_ RVGDI 646_ IQIIS 651_ KDDHN 656_ WWQGK 661_ LENSK 666_ NGTAG 671_ LIPSP 676_ ELQEW 681_ RVACI 686_ AMEKT 691_ KQEQQ 696_ ASCTW 701_ FGKKK 706_ KQYKD 711_ KYLAK 716_ HNAVF 721_ DQLDL 726_ VTYEE 731_ VVKLP 736_ AFKRK 741_ TLVLL 746_ GAHGV 751_ GRRHI 756_ KNTLI 761_ TKHPD 766_ RFAYP 771_ IPHTT 776_ RPPKK 781_ DEENG 786_ KNYYF 791_ VSHDQ 796_ MMQDI 801_ SNNEY 806_ LEYGS 811_ HEDAM 816_ YGTKL 821_ ETIRK 826_ IHEQG 831_ LIAIL 836_ DVEPQ 841_ ALKVL 846_ RTAEF 851_ APFVV 856_ FIAAP 861_ TITPG 866_ LNEDE 871_ SLQRL 876_ QKESD 881_ ILQRT 886_ YAHYF 891_ DLTII 896_ NNEID 901_ ETIRH 906_ LEEAV 911_ ELVCT 916_ APQWV 921_PVSWV
1: Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity)