Proepiregulin [Cleaved into: Epiregulin (EPR)]
1_MTAGR 6_ RMEML 11_ CAGRV 16_ PALLL 21_ CLGFH 26_ LLQAV 31_ LSTTV 36_ IPSCI 41_ PGESS 46_ DNCTA 51_ LVQTE 56_ DNPRV 61_ AQVSI 66_ TKCSS 71_ DMNGY 76_ CLHGQ 81_ CIYLV 86_ DMSQN 91_ YCRCE 96_ VGYTG 101_ VRCEH 106_ FFLTV 111_ HQPLS 116_ KEYVA 121_ LTVIL 126_ IILFL 131_ ITVVG 136_ STYYF 141_ CRWYR 146_ NRKSK 151_ EPKKE 156_ YERVT 161_SGDPE
1: Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357)