Calsequestrin-2 (Calsequestrin, cardiac muscle isoform)
1_MKRTH 6_ LFIVG 11_ IYFLS 16_ SCRAE 21_ EGLNF 26_ PTYDG 31_ KDRVV 36_ SLSEK 41_ NFKQV 46_ LKKYD 51_ LLCLY 56_ YHEPV 61_ SSDKV 66_ TQKQF 71_ QLKEI 76_ VLELV 81_ AQVLE 86_ HKAIG 91_ FVMVD 96_ AKKEA 101_ KLAKK 106_ LGFDE 111_ EGSLY 116_ ILKGD 121_ RTIEF 126_ DGEFA 131_ ADVLV 136_ EFLLD 141_ LIEDP 146_ VEIIS 151_ SKLEV 156_ QAFER 161_ IEDYI 166_ KLIGF 171_ FKSED 176_ SEYYK 181_ AFEEA 186_ AEHFQ 191_ PYIKF 196_ FATFD 201_ KGVAK 206_ KLSLK 211_ MNEVD 216_ FYEPF 221_ MDEPI 226_ AIPNK 231_ PYTEE 236_ ELVEF 241_ VKEHQ 246_ RPTLR 251_ RLRPE 256_ EMFET 261_ WEDDL 266_ NGIHI 271_ VAFAE 276_ KSDPD 281_ GYEFL 286_ EILKQ 291_ VARDN 296_ TDNPD 301_ LSILW 306_ IDPDD 311_ FPLLV 316_ AYWEK 321_ TFKID 326_ LFRPQ 331_ IGVVN 336_ VTDAD 341_ SVWME 346_ IPDDD 351_ DLPTA 356_ EELED 361_ WIEDV 366_ LSGKI 371_ NTEDD 376_ DEDDD 381_ DDDNS 386_ DEEDN 391_DDSDD
1: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats