Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
1_MGRGS 6_ GTFER 11_ LLDKA 16_ TSQLL 21_ LETDW 26_ ESILQ 31_ ICDLI 36_ RQGDT 41_ QAKYA 46_ VNSIK 51_ KKVND 56_ KNPHV 61_ ALYAL 66_ EVMES 71_ VVKNC 76_ GQTVH 81_ DEVAN 86_ KQTME 91_ ELKDL 96_ LKRQV 101_ EVNVR 106_ NKILY 111_ LIQAW 116_ AHAFR 121_ NEPKY 126_ KVVQD 131_ TYQIM 136_ KVEGH 141_ VFPEF 146_ KESDA 151_ MFAAE 156_ RAPDW 161_ VDAEE 166_ CHRCR 171_ VQFGV 176_ MTRKH 181_ HCRAC 186_ GQIFC 191_ GKCSS 196_ KYSTI 201_ PKFGI 206_ EKEVR 211_ VCEPC 216_ YEQLN 221_ RKAEG 226_ KATST 231_ TELPP 236_ EYLTS 241_ PLSQQ 246_ SQLPP 251_ KRDET 256_ ALQEE 261_ EELQL 266_ ALALS 271_ QSEAE 276_ EKERL 281_ RQKST 286_ YTSYP 291_ KAEPM 296_ PSASS 301_ APPAS 306_ SLYSS 311_ PVNSS 316_ APLAE 321_ DIDPE 326_ LARYL 331_ NRNYW 336_ EKKQE 341_ EARKS 346_ PTPSA 351_ PVPLT 356_ EPAAQ 361_ PGEGH 366_ AAPTN 371_ VVENP 376_ LPETD 381_ SQPIP 386_ PSGGP 391_ FSEPQ 396_ FHNGE 401_ SEESH 406_ EQFLK 411_ ALQNA 416_ VTTFV 421_ NRMKS 426_ NHMRG 431_ RSITN 436_ DSAVL 441_ SLFQS 446_ INGMH 451_ PQLLE 456_ LLNQL 461_ DERRL 466_ YYEGL 471_ QDKLA 476_ QIRDA 481_ RGALS 486_ ALREE 491_ HREKL 496_ RRAAE 501_ EAERQ 506_ RQIQL 511_ AQKLE 516_ IMRQK 521_ KQEYL 526_ EVQRQ 531_ LAIQR 536_ LQEQE 541_ KERQM 546_ RLEQQ 551_ KQTVQ 556_ MRAQM 561_ PAFPL 566_ PYAQL 571_ QAMPA 576_ AGGVL 581_ YQPSG 586_ PASFP 591_ STFSP 596_ AGSVE 601_ GSPMH 606_ GVYMS 611_ QPAPA 616_ AGPYP 621_ SMPST 626_ AADPS 631_ MVSAY 636_ MYPAG 641_ ATGAQ 646_ AAPQA 651_ QAGPT 656_ ASPAY 661_ SSYQP 666_ TPTAG 671_ YQNVA 676_ SQAPQ 681_ SLPAI 686_ SQPPQ 691_ SSTMG 696_ YMGSQ 701_ SVSMG 706_ YQPYN 711_ MQNLM 716_ TTLPS 721_ QDASL 726_ PPQQP 731_ YIAGQ 736_ QPMYQ 741_ QMAPS 746_ GGPPQ 751_ QQPPV 756_ AQQPQ 761_ AQGPP 766_ AQGSE 771_AQLIS
1: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation