Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
1_MDRSK 6_ ENCIS 11_ GPVKA 16_ TAPVG 21_ GPKRV 26_ LVTQQ 31_ FPCQN 36_ PLPVN 41_ SGQAQ 46_ RVLCP 51_ SNSSQ 56_ RIPLQ 61_ AQKLV 66_ SSHKP 71_ VQNQK 76_ QKQLQ 81_ ATSVP 86_ HPVSR 91_ PLNNT 96_ QKSKQ 101_ PLPSA 106_ PENNP 111_ EEELA 116_ SKQKN 121_ EESKK 126_ RQWAL 131_ EDFEI 136_ GRPLG 141_ KGKFG 146_ NVYLA 151_ REKQS 156_ KFILA 161_ LKVLF 166_ KAQLE 171_ KAGVE 176_ HQLRR 181_ EVEIQ 186_ SHLRH 191_ PNILR 196_ LYGYF 201_ HDATR 206_ VYLIL 211_ EYAPL 216_ GTVYR 221_ ELQKL 226_ SKFDE 231_ QRTAT 236_ YITEL 241_ ANALS 246_ YCHSK 251_ RVIHR 256_ DIKPE 261_ NLLLG 266_ SAGEL 271_ KIADF 276_ GWSVH 281_ APSSR 286_ RTTLC 291_ GTLDY 296_ LPPEM 301_ IEGRM 306_ HDEKV 311_ DLWSL 316_ GVLCY 321_ EFLVG 326_ KPPFE 331_ ANTYQ 336_ ETYKR 341_ ISRVE 346_ FTFPD 351_ FVTEG 356_ ARDLI 361_ SRLLK 366_ HNPSQ 371_ RPMLR 376_ EVLEH 381_ PWITA 386_ NSSKP 391_ SNCQN 396_KESAS
1: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735)