Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29)
1_MGSRD 6_ HLFKV 11_ LVVGD 16_ AAVGK 21_ TSLVQ 26_ RYSQD 31_ SFSKH 36_ YKSTV 41_ GVDFA 46_ LKVLQ 51_ WSDYE 56_ IVRLQ 61_ LWDIA 66_ GQERF 71_ TSMTR 76_ LYYRD 81_ ASACV 86_ IMFDV 91_ TNATT 96_ FSNSQ 101_ RWKQD 106_ LDSKL 111_ TLPNG 116_ EPVPC 121_ LLLAN 126_ KCDLS 131_ PWAVS 136_ RDQID 141_ RFSKE 146_ NGFTG 151_ WTETS 156_ VKENK 161_ NINEA 166_ MRVLI 171_ EKMMR 176_ NSTED 181_ IMSLS 186_ TQGDY 191_ INLQT 196_KSSSW
1: The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815, PubMed:38127736). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.typhi) epithelial cell infection (PubMed:22042847)