Vacuolar protein sorting-associated protein 26C (Down syndrome critical region protein 3) (Down syndrome critical region protein A)
1_MGTAL 6_ DIKIK 11_ RANKV 16_ YHAGE 21_ VLSGV 26_ VVISS 31_ KDSVQ 36_ HQGVS 41_ LTMEG 46_ TVNLQ 51_ LSAKS 56_ VGVFE 61_ AFYNS 66_ VKPIQ 71_ IINST 76_ IEMVK 81_ PGKFP 86_ SGKTE 91_ IPFEF 96_ PLHLK 101_ GNKVL 106_ YETYH 111_ GVFVN 116_ IQYTL 121_ RCDMK 126_ RSLLA 131_ KDLTK 136_ TCEFI 141_ VHSAP 146_ QKGKF 151_ TPSPV 156_ DFTIT 161_ PETLQ 166_ NVKER 171_ ALLPK 176_ FLLRG 181_ HLNST 186_ NCVIT 191_ QPLTG 196_ ELVVE 201_ SSEAA 206_ IRSVE 211_ LQLVR 216_ VETCG 221_ CAEGY 226_ ARDAT 231_ EIQNI 236_ QIADG 241_ DVCRG 246_ LSVPI 251_ YMVFP 256_ RLFTC 261_ PTLET 266_ TNFKV 271_ EFEVN 276_ IVVLL 281_ HPDHL 286_ ITENF 291_PLKLC
1: Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:39587083, PubMed:38062209, PubMed:38459129). Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079, PubMed:37172566, PubMed:39587083, PubMed:38062209, PubMed:38459129). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079, PubMed:39587083)
2: (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface