Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Phytanate--CoA ligase) (EC 6.2.1.24) (Solute carrier family 27 member 2) (THCA-CoA ligase) (EC 6.2.1.7) (Very long-chain-fatty-acid-CoA ligase)
1_MLSAI 6_ YTVLA 11_ GLLFL 16_ PLLVN 21_ LCCPY 26_ FFQDI 31_ GYFLK 36_ VAAVG 41_ RRVRS 46_ YGKRR 51_ PARTI 56_ LRAFL 61_ EKARQ 66_ TPHKP 71_ FLLFR 76_ DETLT 81_ YAQVD 86_ RRSNQ 91_ VARAL 96_ HDHLG 101_ LRQGD 106_ CVALL 111_ MGNEP 116_ AYVWL 121_ WLGLV 126_ KLGCA 131_ MACLN 136_ YNIRA 141_ KSLLH 146_ CFQCC 151_ GAKVL 156_ LVSPE 161_ LQAAV 166_ EEILP 171_ SLKKD 176_ DVSIY 181_ YVSRT 186_ SNTDG 191_ IDSFL 196_ DKVDE 201_ VSTEP 206_ IPESW 211_ RSEVT 216_ FSTPA 221_ LYIYT 226_ SGTTG 231_ LPKAA 236_ MITHQ 241_ RIWYG 246_ TGLTF 251_ VSGLK 256_ ADDVI 261_ YITLP 266_ FYHSA 271_ ALLIG 276_ IHGCI 281_ VAGAT 286_ LALRT 291_ KFSAS 296_ QFWDD 301_ CRKYN 306_ VTVIQ 311_ YIGEL 316_ LRYLC 321_ NSPQK 326_ PNDRD 331_ HKVRL 336_ ALGNG 341_ LRGDV 346_ WRQFV 351_ KRFGD 356_ ICIYE 361_ FYAAT 366_ EGNIG 371_ FMNYA 376_ RKVGA 381_ VGRVN 386_ YLQKK 391_ IITYD 396_ LIKYD 401_ VEKDE 406_ PVRDE 411_ NGYCV 416_ RVPKG 421_ EVGLL 426_ VCKIT 431_ QLTPF 436_ NGYAG 441_ AKAQT 446_ EKKKL 451_ RDVFK 456_ KGDLY 461_ FNSGD 466_ LLMVD 471_ HENFI 476_ YFHDR 481_ VGDTF 486_ RWKGE 491_ NVATT 496_ EVADT 501_ VGLVD 506_ FVQEV 511_ NVYGV 516_ HVPDH 521_ EGRIG 526_ MASIK 531_ MKENH 536_ EFDGK 541_ KLFQH 546_ IADYL 551_ PSYAR 556_ PRFLR 561_ IQDTI 566_ EITGT 571_ FKHRK 576_ MTLVE 581_ EGFNP 586_ AVIKD 591_ ALYFL 596_ DDTAK 601_ MYVPM 606_ TEDIY 611_NAISA
1: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:10198260, PubMed:10749848, PubMed:11980911, PubMed:20530735, PubMed:22022213, PubMed:24269233). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:10198260, PubMed:10749848, PubMed:11980911, PubMed:20530735, PubMed:22022213, PubMed:24269233). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:20530735). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). May contribute to the synthesis of sphingosine-1-phosphate (PubMed:24269233). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). However, it is not critical for THCA activation and bile synthesis in vivo (PubMed:20530735)
2: Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids (PubMed:10198260, PubMed:21768100). Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol (PubMed:21768100)
3: Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids