Gene name: GAK

Uniprot entry:

O14976

Protein names:

Cyclin-G-associated kinase (EC 2.7.11.1)

Protein sequence:

1_MSLLQ 6_ SALDF 11_ LAGPG 16_ SLGGA 21_ SGRDQ 26_ SDFVG 31_ QTVEL 36_ GELRL 41_ RVRRV 46_ LAEGG 51_ FAFVY 56_ EAQDV 61_ GSGRE 66_ YALKR 71_ LLSNE 76_ EEKNR 81_ AIIQE 86_ VCFMK 91_ KLSGH 96_ PNIVQ 101_ FCSAA 106_ SIGKE 111_ ESDTG 116_ QAEFL 121_ LLTEL 126_ CKGQL 131_ VEFLK 136_ KMESR 141_ GPLSC 146_ DTVLK 151_ IFYQT 156_ CRAVQ 161_ HMHRQ 166_ KPPII 171_ HRDLK 176_ VENLL 181_ LSNQG 186_ TIKLC 191_ DFGSA 196_ TTISH 201_ YPDYS 206_ WSAQR 211_ RALVE 216_ EEITR 221_ NTTPM 226_ YRTPE 231_ IIDLY 236_ SNFPI 241_ GEKQD 246_ IWALG 251_ CILYL 256_ LCFRQ 261_ HPFED 266_ GAKLR 271_ IVNGK 276_ YSIPP 281_ HDTQY 286_ TVFHS 291_ LIRAM 296_ LQVNP 301_ EERLS 306_ IAEVV 311_ HQLQE 316_ IAAAR 321_ NVNPK 326_ SPITE 331_ LLEQN 336_ GGYGS 341_ ATLSR 346_ GPPPP 351_ VGPAG 356_ SGYSG 361_ GLALA 366_ EYDQP 371_ YGGFL 376_ DILRG 381_ GTERL 386_ FTNLK 391_ DTSSK 396_ VIQSV 401_ ANYAK 406_ GDLDI 411_ SYITS 416_ RIAVM 421_ SFPAE 426_ GVESA 431_ LKNNI 436_ EDVRL 441_ FLDSK 446_ HPGHY 451_ AVYNL 456_ SPRTY 461_ RPSRF 466_ HNRVS 471_ ECGWA 476_ ARRAP 481_ HLHTL 486_ YNICR 491_ NMHAW 496_ LRQDH 501_ KNVCV 506_ VHCMD 511_ GRAAS 516_ AVAVC 521_ SFLCF 526_ CRLFS 531_ TAEAA 536_ VYMFS 541_ MKRCP 546_ PGIWP 551_ SHKRY 556_ IEYMC 561_ DMVAE 566_ EPITP 571_ HSKPI 576_ LVRAV 581_ VMTPV 586_ PLFSK 591_ QRSGC 596_ RPFCE 601_ VYVGD 606_ ERVAS 611_ TSQEY 616_ DKMRD 621_ FKIED 626_ GKAVI 631_ PLGVT 636_ VQGDV 641_ LIVIY 646_ HARST 651_ LGGRL 656_ QAKMA 661_ SMKMF 666_ QIQFH 671_ TGFVP 676_ RNATT 681_ VKFAK 686_ YDLDA 691_ CDIQE 696_ KYPDL 701_ FQVNL 706_ EVEVE 711_ PRDRP 716_ SREAP 721_ PWENS 726_ SMRGL 731_ NPKIL 736_ FSSRE 741_ EQQDI 746_ LSKFG 751_ KPELP 756_ RQPGS 761_ TAQYD 766_ AGAGS 771_ PEAEP 776_ TDSDS 781_ PPSSS 786_ ADASR 791_ FLHTL 796_ DWQEE 801_ KEAET 806_ GAENA 811_ SSKES 816_ ESALM 821_ EDRDE 826_ SEVSD 831_ EGGSP 836_ ISSEG 841_ QEPRA 846_ DPEPP 851_ GLAAG 856_ LVQQD 861_ LVFEV 866_ ETPAV 871_ LPEPV 876_ PQEDG 881_ VDLLG 886_ LHSEV 891_ GAGPA 896_ VPPQA 901_ CKAPS 906_ SNTDL 911_ LSCLL 916_ GPPEA 921_ ASQGP 926_ PEDLL 931_ SEDPL 936_ LLASP 941_ APPLS 946_ VQSTP 951_ RGGPP 956_ AAADP 961_ FGPLL 966_ PSSGN 971_ NSQPC 976_ SNPDL 981_ FGEFL 986_ NSDSV 991_ TVPPS 996_ FPSAH 1001_ SAPPP 1006_ SCSAD 1011_ FLHLG 1016_ DLPGE 1021_ PSKMT 1026_ ASSSN 1031_ PDLLG 1036_ GWAAW 1041_ TETAA 1046_ SAVAP 1051_ TPATE 1056_ GPLFS 1061_ PGGQP 1066_ APCGS 1071_ QASWT 1076_ KSQNP 1081_ DPFAD 1086_ LGDLS 1091_ SGLQG 1096_ SPAGF 1101_ PPGGF 1106_ IPKTA 1111_ TTPKG 1116_ SSSWQ 1121_ TSRPP 1126_ AQGAS 1131_ WPPQA 1136_ KPPPK 1141_ ACTQP 1146_ RPNYA 1151_ SNFSV 1156_ IGARE 1161_ ERGVR 1166_ APSFA 1171_ QKPKV 1176_ SENDF 1181_ EDLLS 1186_ NQGFS 1191_ SRSDK 1196_ KGPKT 1201_ IAEMR 1206_ KQDLA 1211_ KDTDP 1216_ LKLKL 1221_ LDWIE 1226_ GKERN 1231_ IRALL 1236_ STLHT 1241_ VLWDG 1246_ ESRWT 1251_ PVGMA 1256_ DLVAP 1261_ EQVKK 1266_ HYRRA 1271_ VLAVH 1276_ PDKAA 1281_ GQPYE 1286_ QHAKM 1291_ IFMEL 1296_ NDAWS 1301_ EFENQ 1306_GSRPL

Protein annotations

Protein functions:

1: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706)