Antizyme inhibitor 1 (AZI) (AZI1) (Ornithine decarboxylase antizyme inhibitor)
1_MKGFI 6_ DDANY 11_ SVGLL 16_ DEGTN 21_ LGNVI 26_ DNYVY 31_ EHTLT 36_ GKNAF 41_ FVGDL 46_ GKIVK 51_ KHSQW 56_ QNVVA 61_ QIKPF 66_ YTVKC 71_ NSAPA 76_ VLEIL 81_ AALGT 86_ GFACS 91_ SKNEM 96_ ALVQE 101_ LGVPP 106_ ENIIY 111_ ISPCK 116_ QVSQI 121_ KYAAK 126_ VGVNI 131_ LTCDN 136_ EIELK 141_ KIARN 146_ HPNAK 151_ VLLHI 156_ ATEDN 161_ IGGEE 166_ GNMKF 171_ GTTLK 176_ NCRHL 181_ LECAK 186_ ELDVQ 191_ IIGVK 196_ FHVSS 201_ ACKES 206_ QVYVH 211_ ALSDA 216_ RCVFD 221_ MAGEI 226_ GFTMN 231_ MLDIG 236_ GGFTG 241_ TEFQL 246_ EEVNH 251_ VISPL 256_ LDIYF 261_ PEGSG 266_ VKIIS 271_ EPGSY 276_ YVSSA 281_ FTLAV 286_ NIIAK 291_ KVVEN 296_ DKFPS 301_ GVEKT 306_ GSDEP 311_ AFMYY 316_ MNDGV 321_ YGSFA 326_ SKLSE 331_ DLNTI 336_ PEVHK 341_ KYKED 346_ EPLFT 351_ SSLWG 356_ PSCDE 361_ LDQIV 366_ ESCLL 371_ PELNV 376_ GDWLI 381_ FDNMG 386_ ADSFH 391_ EPSAF 396_ NDFQR 401_ PAIYY 406_ MMSFS 411_ DWYEM 416_ QDAGI 421_ TSDSM 426_ MKNFF 431_ FVPSC 436_ IQLSQ 441_EDSFS
1: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240)