Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1)
1_MEVPP 6_ RLSHV 11_ PPPLF 16_ PSAPA 21_ TLASR 26_ SLSHW 31_ RPRPP 36_ RQLAP 41_ LLPSL 46_ APSSA 51_ RQGAR 56_ RAQRH 61_ VTAQQ 66_ PSRLA 71_ GGAAI 76_ KGGRR 81_ RRPDL 86_ FRRHF 91_ KSSSI 96_ QRSAA 101_ AAAAT 106_ RTARQ 111_ HPPAD 116_ SSVTM 121_ EDMNE 126_ YSNIE 131_ EFAEG 136_ SKINA 141_ SKNQQ 146_ DDGKM 151_ FIGGL 156_ SWDTS 161_ KKDLT 166_ EYLSR 171_ FGEVV 176_ DCTIK 181_ TDPVT 186_ GRSRG 191_ FGFVL 196_ FKDAA 201_ SVDKV 206_ LELKE 211_ HKLDG 216_ KLIDP 221_ KRAKA 226_ LKGKE 231_ PPKKV 236_ FVGGL 241_ SPDTS 246_ EEQIK 251_ EYFGA 256_ FGEIE 261_ NIELP 266_ MDTKT 271_ NERRG 276_ FCFIT 281_ YTDEE 286_ PVKKL 291_ LESRY 296_ HQIGS 301_ GKCEI 306_ KVAQP 311_ KEVYR 316_ QQQQQ 321_ QKGGR 326_ GAAAG 331_ GRGGT 336_ RGRGR 341_ GQGQN 346_ WNQGF 351_ NNYYD 356_ QGYGN 361_ YNSAY 366_ GGDQN 371_ YSGYG 376_ GYDYT 381_ GYNYG 386_ NYGYG 391_ QGYAD 396_ YSGQQ 401_ STYGK 406_ ASRGG 411_GNHQN
1: Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence