Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
1_MPAIM 6_ TMLAD 11_ HAARQ 16_ LLDFS 21_ QKLDI 26_ NLLDN 31_ VVNCL 36_ YHGEG 41_ AQQRM 46_ AQEVL 51_ THLKE 56_ HPDAW 61_ TRVDT 66_ ILEFS 71_ QNMNT 76_ KYYGL 81_ QILEN 86_ VIKTR 91_ WKILP 96_ RNQCE 101_ GIKKY 106_ VVGLI 111_ IKTSS 116_ DPTCV 121_ EKEKV 126_ YIGKL 131_ NMILV 136_ QILKQ 141_ EWPKH 146_ WPTFI 151_ SDIVG 156_ ASRTS 161_ ESLCQ 166_ NNMVI 171_ LKLLS 176_ EEVFD 181_ FSSGQ 186_ ITQVK 191_ SKHLK 196_ DSMCN 201_ EFSQI 206_ FQLCQ 211_ FVMEN 216_ SQNAP 221_ LVHAT 226_ LETLL 231_ RFLNW 236_ IPLGY 241_ IFETK 246_ LISTL 251_ IYKFL 256_ NVPMF 261_ RNVSL 266_ KCLTE 271_ IAGVS 276_ VSQYE 281_ EQFVT 286_ LFTLT 291_ MMQLK 296_ QMLPL 301_ NTNIR 306_ LAYSN 311_ GKDDE 316_ QNFIQ 321_ NLSLF 326_ LCTFL 331_ KEHDQ 336_ LIEKR 341_ LNLRE 346_ TLMEA 351_ LHYML 356_ LVSEV 361_ EETEI 366_ FKICL 371_ EYWNH 376_ LAAEL 381_ YRESP 386_ FSTSA 391_ SPLLS 396_ GSQHF 401_ DVPPR 406_ RQLYL 411_ PMLFK 416_ VRLLM 421_ VSRMA 426_ KPEEV 431_ LVVEN 436_ DQGEV 441_ VREFM 446_ KDTDS 451_ INLYK 456_ NMRET 461_ LVYLT 466_ HLDYV 471_ DTERI 476_ MTEKL 481_ HNQVN 486_ GTEWS 491_ WKNLN 496_ TLCWA 501_ IGSIS 506_ GAMHE 511_ EDEKR 516_ FLVTV 521_ IKDLL 526_ GLCEQ 531_ KRGKD 536_ NKAII 541_ ASNIM 546_ YIVGQ 551_ YPRFL 556_ RAHWK 561_ FLKTV 566_ VNKLF 571_ EFMHE 576_ THDGV 581_ QDMAC 586_ DTFIK 591_ IAQKC 596_ RRHFV 601_ QVQVG 606_ EVMPF 611_ IDEIL 616_ NNINT 621_ IICDL 626_ QPQQV 631_ HTFYE 636_ AVGYM 641_ IGAQT 646_ DQTVQ 651_ EHLIE 656_ KYMLL 661_ PNQVW 666_ DSIIQ 671_ QATKN 676_ VDILK 681_ DPETV 686_ KQLGS 691_ ILKTN 696_ VRACK 701_ AVGHP 706_ FVIQL 711_ GRIYL 716_ DMLNV 721_ YKCLS 726_ ENISA 731_ AIQAN 736_ GEMVT 741_ KQPLI 746_ RSMRT 751_ VKRET 756_ LKLIS 761_ GWVSR 766_ SNDPQ 771_ MVAEN 776_ FVPPL 781_ LDAVL 786_ IDYQR 791_ NVPAA 796_ REPEV 801_ LSTMA 806_ IIVNK 811_ LGGHI 816_ TAEIP 821_ QIFDA 826_ VFECT 831_ LNMIN 836_ KDFEE 841_ YPEHR 846_ TNFFL 851_ LLQAV 856_ NSHCF 861_ PAFLA 866_ IPPTQ 871_ FKLVL 876_ DSIIW 881_ AFKHT 886_ MRNVA 891_ DTGLQ 896_ ILFTL 901_ LQNVA 906_ QEEAA 911_ AQSFY 916_ QTYFC 921_ DILQH 926_ IFSVV 931_ TDTSH 936_ TAGLT 941_ MHASI 946_ LAYMF 951_ NLVEE 956_ GKIST 961_ SLNPG 966_ NPVNN 971_ QIFLQ 976_ EYVAN 981_ LLKSA 986_ FPHLQ 991_ DAQVK 996_ LFVTG 1001_ LFSLN 1006_ QDIPA 1011_ FKEHL 1016_ RDFLV 1021_ QIKEF 1026_ AGEDT 1031_ SDLFL 1036_ EEREI 1041_ ALRQA 1046_ DEEKH 1051_ KRQMS 1056_ VPGIF 1061_ NPHEI 1066_PEEMC
1: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap
2: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization