Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta)
1_MSSAA 6_ ENGEA 11_ APGKQ 16_ NEEKT 21_ YKKTA 26_ SSAIK 31_ GAIQL 36_ GIGYT 41_ VGNLT 46_ SKPER 51_ DVLMQ 56_ DFYVV 61_ ESVFL 66_ PSEGS 71_ NLTPA 76_ HHYPD 81_ FRFKT 86_ YAPLA 91_ FRYFR 96_ ELFGI 101_ KPDDY 106_ LYSIC 111_ SEPLI 116_ ELSNP 121_ GASGS 126_ LFFVT 131_ SDDEF 136_ IIKTV 141_ QHKEA 146_ EFLQK 151_ LLPGY 156_ YMNLN 161_ QNPRT 166_ LLPKF 171_ YGLYC 176_ MQSGG 181_ INIRI 186_ VVMNN 191_ VLPRS 196_ MRMHF 201_ TYDLK 206_ GSTYK 211_ RRASR 216_ KEREK 221_ SNPTF 226_ KDLDF 231_ LQDMH 236_ EGLYF 241_ DTETY 246_ NALMK 251_ TLQRD 256_ CRVLE 261_ SFKIM 266_ DYSLL 271_ LGIHF 276_ LDHSL 281_ KEKEE 286_ ETPQN 291_ VPDAK 296_ RTGMQ 301_ KVLYS 306_ TAMES 311_ IQGPG 316_ KSGDG 321_ IITEN 326_ PDTMG 331_ GIPAK 336_ SHRGE 341_ KLLLF 346_ MGIID 351_ ILQSY 356_ RLMKK 361_ LEHSW 366_ KALVY 371_ DGDTV 376_ SVHRP 381_ SFYAD 386_ RFLKF 391_ MNSRV 396_ FKKIQ 401_ ALKAS 406_ PSKKR 411_ CNSIA 416_ ALKAT 421_ SQEIV 426_ SSISQ 431_ EWKDE 436_ KRDLL 441_ TEGQS 446_ FSSLD 451_ EEALG 456_ SRHRP 461_ DLVPS 466_ TPSLF 471_ EAASL 476_ ATTIS 481_ SSSLY 486_ VNEHY 491_ PHDRP 496_ TLYSN 501_ SKGLP 506_ SSSTF 511_ TLEEG 516_ TIYLT 521_ AEPNT 526_ LEVQD 531_DNASV
1: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity)