Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1)
1_MFYVI 6_ GGITV 11_ SVVAF 16_ FFTIK 21_ FLFEL 26_ AARVV 31_ SFLQN 36_ EDRER 41_ RGDRT 46_ IYDYV 51_ RGNYL 56_ DPRSC 61_ KVSWD 66_ WKDPY 71_ EVGHS 76_ MAFRV 81_ HLFYK 86_ NGQPF 91_ PAHRP 96_ VGLRV 101_ HISHV 106_ ELAVE 111_ IPVTQ 116_ EVLQE 121_ PNSNV 126_ VKVAF 131_ TVRKA 136_ GRYEI 141_ TVKLG 146_ GLNVA 151_ YSPYY 156_ KIFQP 161_ GMVVP 166_ SKTKI 171_ VCHFS 176_ TLVLT 181_ CGQPH 186_ TLQIV 191_ PRDEY 196_ DNPTN 201_ NSMSL 206_ RDEHN 211_ YTLSI 216_ HELGP 221_ QEEES 226_ TGVSF 231_ EKSVT 236_ SNRQT 241_ FQVFL 246_ RLTLH 251_ SRGCF 256_ HACIS 261_ YQNQP 266_ INNGE 271_ FDIIV 276_ LSEDE 281_ KNIVE 286_ RNVST 291_ SGVSI 296_ YFEAY 301_ LYNAT 306_ NCSST 311_ PWHLP 316_ PMHMT 321_ SSQRR 326_ PSTAV 331_ DEEDE 336_ DSPSE 341_ CHTPE 346_ KVKKP 351_ KKVYC 356_ YVSPK 361_ QFSVK 366_ EFYLK 371_ IIPWR 376_ LYTFR 381_ VCPGT 386_ KFSYL 391_ GPDPV 396_ HKLLT 401_ LVVDD 406_ GIQPP 411_ VELSC 416_ KERNI 421_ LAATF 426_ IRSLH 431_ KNIGG 436_ SETFQ 441_ DKVNF 446_ FQREL 451_ RQVHM 456_ KRPHS 461_ KVTLK 466_ VSRHA 471_ LLESS 476_ LKATR 481_ NFSIS 486_ DWSKN 491_ FEVVF 496_ QDEEA 501_ LDWGG 506_ PRREW 511_ FELIC 516_ KALFD 521_ TTNQL 526_ FTRFS 531_ DNNQA 536_ LVHPN 541_ PNRPA 546_ HLRLK 551_ MYEFA 556_ GRLVG 561_ KCLYE 566_ SSLGG 571_ AYKQL 576_ VRARF 581_ TRSFL 586_ AQIIG 591_ LRMHY 596_ KYFET 601_ DDPEF 606_ YKSKV 611_ CFILN 616_ NDMSE 621_ MELVF 626_ AEEKY 631_ NKSGQ 636_ LDKVV 641_ ELMTG 646_ GAQTP 651_ VTNAN 656_ KIFYL 661_ NLLAQ 666_ YRLAS 671_ QVKEE 676_ VEHFL 681_ KGLNE 686_ LVPEN 691_ LLAIF 696_ DENEL 701_ ELLMC 706_ GTGDI 711_ SVSDF 716_ KAHAV 721_ VVGGS 726_ WHFRE 731_ KVMRW 736_ FWTVV 741_ SSLTQ 746_ EELAR 751_ LLQFT 756_ TGSSQ 761_ LPPGG 766_ FAALC 771_ PSFQI 776_ IAAPT 781_ HSTLP 786_ TAHTC 791_ FNQLC 796_ LPTYD 801_ SYEEV 806_ HRMLQ 811_ LAISE 816_GCEGF
1: E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages (PubMed:25752577). E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:23479728, PubMed:31578312). Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro (PubMed:23479728). Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312)