Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)
1_MDQEG 6_ GGDGQ 11_ KAPSF 16_ QWRNY 21_ KLIVD 26_ PALDP 31_ ALRRP 36_ SQKVY 41_ RYDGV 46_ HFSVN 51_ DSKYI 56_ PVEDL 61_ QDPRC 66_ HVRSK 71_ NRDFS 76_ LPVPK 81_ FKLDE 86_ FYIGQ 91_ IPLKE 96_ VTFAR 101_ LNDNV 106_ RETFL 111_ KDMCR 116_ KYGEV 121_ EEVEI 126_ LLHPR 131_ TRKHL 136_ GLARV 141_ LFTST 146_ RGAKE 151_ TVKNL 156_ HLTSV 161_ MGNII 166_ HAQLD 171_ IKGQQ 176_ RMKYY 181_ ELIVN 186_ GSYTP 191_ QTVPT 196_ GGKAL 201_ SEKFQ 206_ GSGAA 211_ TETAE 216_ SRRRS 221_ SSDTA 226_ AYPAG 231_ TTAVG 236_ TPGNG 241_ TPCSQ 246_ DTSFS 251_ SSRQD 256_ TPSSF 261_ GQFTP 266_ QSSQG 271_ TPYTS 276_ RGSTP 281_ YSQDS 286_ AYSSS 291_ TTSTS 296_ FKPRR 301_ SENSY 306_ QDAFS 311_ RRHFS 316_ ASSAS 321_ TTAST 326_ AIAAT 331_ TAATA 336_ SSSAS 341_ SSSLS 346_ SSSSS 351_ SSSSS 356_ SSQFR 361_ SSDAN 366_ YPAYY 371_ ESWNR 376_ YQRHT 381_ SYPPR 386_ RATRE 391_ EPPGA 396_ PFAEN 401_ TAERF 406_ PPSYT 411_ SYLPP 416_ EPSRP 421_ TDQDY 426_ RPPAS 431_ EAPPP 436_ EPPEP 441_ GGGGG 446_ GGGPS 451_ PEREE 456_ VRTSP 461_ RPASP 466_ ARSGS 471_ PAPET 476_ TNESV 481_ PFAQH 486_ SSLDS 491_ RIEML 496_ LKEQR 501_ SKFSF 506_ LASDT 511_ EEEEE 516_ NSSMV 521_ LGARD 526_ TGSEV 531_ PSGSG 536_ HGPCT 541_ PPPAP 546_ ANFED 551_ VAPTG 556_ SGEPG 561_ ATRES 566_ PKANG 571_ QNQAS 576_ PCSSG 581_ DDMEI 586_ SDDDR 591_ GGSPP 596_ PAPTP 601_ PQQPP 606_ PPPPP 611_ PPPPP 616_ PYLAS 621_ LPLGY 626_ PPHQP 631_ AYLLP 636_ PRPDG 641_ PPPPE 646_ YPPPP 651_ PPPPH 656_ IYDFV 661_ NSLEL 666_ MDRLG 671_ AQWGG 676_ MPMSF 681_ QMQTQ 686_ MLTRL 691_ HQLRQ 696_ GKGLI 701_ AASAG 706_ PPGGA 711_ FGEAF 716_ LPFPP 721_ PQEAA 726_ YGLPY 731_ ALYAQ 736_ GQEGR 741_ GAYSR 746_ EAYHL 751_ PMPMA 756_ AEPLP 761_ SSSVS 766_ GEEAR 771_ LPPRE 776_ EAELA 781_ EGKTL 786_ PTAGT 791_ VGRVL 796_ AMLVQ 801_ EMKSI 806_ MQRDL 811_ NRKMV 816_ ENVAF 821_ GAFDQ 826_ WWESK 831_ EEKAK 836_ PFQNA 841_ AKQQA 846_ KEEDK 851_ EKTKL 856_ KEPGL 861_ LSLVD 866_ WAKSG 871_ GTTGI 876_ EAFAF 881_ GSGLR 886_ GALRL 891_ PSFKV 896_ KRKEP 901_ SEISE 906_ ASEEK 911_ RPRPS 916_ TPAEE 921_ DEDDP 926_ EQEKE 931_ AGEPG 936_ RPGTK 941_ PPKRD 946_ EERGK 951_ TQGKH 956_ RKSFA 961_ LDSEG 966_ EEASQ 971_ ESSSE 976_ KDEED 981_ DEEDE 986_ EDEDR 991_ EEAVD 996_ TTKKE 1001_ TEVSD 1006_ GEDEE 1011_ SDSSS 1016_ KCSLY 1021_ ADSDG 1026_ ENDST 1031_ SDSES 1036_ SSSSS 1041_ SSSSS 1046_ SSSSS 1051_ SSSSS 1056_ SSSES 1061_ SSEDE 1066_ EEEER 1071_ PAALP 1076_ SASPP 1081_ PREVP 1086_ VPTPA 1091_ PVEVP 1096_ VPERV 1101_ AGSPV 1106_ TPLPE 1111_ QEASP 1116_ ARPAG 1121_ PTEES 1126_ PPSAP 1131_ LRPPE 1136_ PPAGP 1141_ PAPAP 1146_ RPDER 1151_ PSSPI 1156_ PLLPP 1161_ PKKRR 1166_ KTVSF 1171_ SAIEV 1176_ VPAPE 1181_ PPPAT 1186_ PPQAK 1191_ FPGPA 1196_ SRKAP 1201_ RGVER 1206_ TIRNL 1211_ PLDHA 1216_ SLVKS 1221_ WPEEV 1226_ SRGGR 1231_ SRAGG 1236_ RGRLT 1241_ EEEEA 1246_ EPGTE 1251_ VDLAV 1256_ LADLA 1261_ LTPAR 1266_ RGLPA 1271_ LPAVE 1276_ DSEAT 1281_ ETSDE 1286_ AERPR 1291_ PLLSH 1296_ ILLEH 1301_ NYALA 1306_ VKPTP 1311_ PAPAL 1316_ RPPEP 1321_ VPAPA 1326_ ALFSS 1331_ PADEV 1336_ LEAPE 1341_ VVVAE 1346_ AEEPK 1351_ PQQLQ 1356_ QQREE 1361_ GEEEG 1366_ EEEGE 1371_ EEEEE 1376_ SSDSS 1381_ SSSDG 1386_ EGALR 1391_ RRSLR 1396_ SHARR 1401_ RRPPP 1406_ PPPPP 1411_ PPRAY 1416_ EPRSE 1421_ FEQMT 1426_ ILYDI 1431_ WNSGL 1436_ DSEDM 1441_ SYLRL 1446_ TYERL 1451_ LQQTS 1456_ GADWL 1461_ NDTHW 1466_ VHHTI 1471_ TNLTT 1476_ PKRKR 1481_ RPQDG 1486_ PREHQ 1491_ TGSAR 1496_ SEGYY 1501_ PISKK 1506_ EKDKY 1511_ LDVCP 1516_ VSARQ 1521_ LEGVD 1526_ TQGTN 1531_ RVLSE 1536_ RRSEQ 1541_ RRLLS 1546_ AIGTS 1551_ AIMDS 1556_ DLLKL 1561_ NQLKF 1566_ RKKKL 1571_ RFGRS 1576_ RIHEW 1581_ GLFAM 1586_ EPIAA 1591_ DEMVI 1596_ EYVGQ 1601_ NIRQM 1606_ VADMR 1611_ EKRYV 1616_ QEGIG 1621_ SSYLF 1626_ RVDHD 1631_ TIIDA 1636_ TKCGN 1641_ LARFI 1646_ NHCCT 1651_ PNCYA 1656_ KVITI 1661_ ESQKK 1666_ IVIYS 1671_ KQPIG 1676_ VDEEI 1681_ TYDYK 1686_ FPLED 1691_ NKIPC 1696_ LCGTE 1701_SCRGS
1: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223)