NEDD4-binding protein 3 (N4BP3)
1_MATAP 6_ GPAGI 11_ AMGSV 16_ GSLLE 21_ RQDFS 26_ PEELR 31_ AALAG 36_ SRGSR 41_ QPDGL 46_ LRKGL 51_ GQREF 56_ LSYLH 61_ LPKKD 66_ SKSTK 71_ NTKRA 76_ PRNEP 81_ ADYAT 86_ LYYRE 91_ HSRAG 96_ DFSKT 101_ SLPER 106_ GRFDK 111_ CRIRP 116_ SVFKP 121_ TAGNG 126_ KGFLS 131_ MQSLA 136_ SHKGQ 141_ KLWRS 146_ NGSLH 151_ TLACH 156_ PPLSP 161_ GPRAS 166_ QARAQ 171_ LLHAL 176_ SLDEG 181_ GPEPE 186_ PSLSD 191_ SSSGG 196_ SFGRS 201_ PGTGP 206_ SPFSS 211_ SLGHL 216_ NHLGG 221_ SLDRA 226_ SQGPK 231_ EAGPP 236_ AVLSC 241_ LPEPP 246_ PPYEF 251_ SCSSA 256_ EEMGA 261_ VLPET 266_ CEELK 271_ RGLGD 276_ EDGSN 281_ PFTQV 286_ LEERQ 291_ RLWLA 296_ ELKRL 301_ YVERL 306_ HEVTQ 311_ KAERS 316_ ERNLQ 321_ LQLFM 326_ AQQEQ 331_ RRLRK 336_ ELRAQ 341_ QGLAP 346_ EPRAP 351_ GTLPE 356_ ADPSA 361_ RPEEE 366_ ARWEV 371_ CQKTA 376_ EISLL 381_ KQQLR 386_ EAQAE 391_ LAQKL 396_ AEIFS 401_ LKTQL 406_ RGSRA 411_ QAQAQ 416_ DAELV 421_ RLREA 426_ VRSLQ 431_ EQAPR 436_ EEAPG 441_ SCETD 446_ DCKSR 451_ GLLGE 456_ AGGSE 461_ ARDSA 466_ EQLRA 471_ ELLQE 476_ RLRGQ 481_ EQALR 486_ FEQER 491_ RTWQE 496_ EKERV 501_ LRYQR 506_ EIQGG 511_ YMDMY 516_ RRNQA 521_ LEQEL 526_ RALRE 531_ PPTPW 536_SPRLE
1: Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity)