Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B)
1_MHRAV 6_ DPPGA 11_ RAARE 16_ AFALG 21_ GLSCA 26_ GAWSS 31_ CPPHP 36_ PPRSA 41_ WLPGG 46_ RCSAS 51_ IGQPP 56_ LPAPL 61_ PPSHG 66_ SSSGH 71_ PSKPY 76_ YAPGA 81_ PTPRP 86_ LHGKL 91_ ESLHG 96_ CVQAL 101_ LREPA 106_ QPGLW 111_ EQLGQ 116_ LYESE 121_ HDSEE 126_ ATRCY 131_ HSALR 136_ YGGSF 141_ AELGP 146_ RIGRL 151_ QQAQL 156_ WNFHT 161_ GSCQH 166_ RAKVL 171_ PPLEQ 176_ VWNLL 181_ HLEHK 186_ RNYGA 191_ KRGGP 196_ PVKRA 201_ AEPPV 206_ VQPVP 211_ PAALS 216_ GPSGE 221_ EGLSP 226_ GGKRR 231_ RGCNS 236_ EQTGL 241_ PPGLP 246_ LPPPP 251_ LPPPP 256_ PPPPP 261_ PPPPL 266_ PGLAT 271_ SPPFQ 276_ LTKPG 281_ LWSTL 286_ HGDAW 291_ GPERK 296_ GSAPP 301_ ERQEQ 306_ RHSLP 311_ HPYPY 316_ PAPAY 321_ TAHPP 326_ GHRLV 331_ PAAPP 336_ GPGPR 341_ PPGAE 346_ SHGCL 351_ PATRP 356_ PGSDL 361_ RESRV 366_ QRSRM 371_ DSSVS 376_ PAATT 381_ ACVPY 386_ APSRP 391_ PGLPG 396_ TTTSS 401_ SSSSS 406_ SNTGL 411_ RGVEP 416_ NPGIP 421_ GADHY 426_ QTPAL 431_ EVSHH 436_ GRLGP 441_ SAHSS 446_ RKPFL 451_ GAPAA 456_ TPHLS 461_ LPPGP 466_ SSPPP 471_ PPCPR 476_ LLRPP 481_ PPPAW 486_ LKGPA 491_ CRAAR 496_ EDGEI 501_ LEELF 506_ FGTEG 511_ PPRPA 516_ PPPLP 521_ HREGF 526_ LGPPA 531_ SRFSV 536_ GTQDS 541_ HTPPT 546_ PPTPT 551_ TSSSN 556_ SNSGS 561_ HSSSP 566_ AGPVS 571_ FPPPP 576_ YLARS 581_ IDPLP 586_ RPPSP 591_ AQNPQ 596_ DPPLV 601_ PLTLA 606_ LPPAP 611_ PSSCH 616_ QNTSG 621_ SFRRP 626_ ESPRP 631_ RVSFP 636_ KTPEV 641_ GPGPP 646_ PGPLS 651_ KAPQP 656_ VPPGV 661_ GELPA 666_ RGPRL 671_ FDFPP 676_ TPLED 681_ QFEEP 686_ AEFKI 691_ LPDGL 696_ ANIMK 701_ MLDES 706_ IRKEE 711_ EQQQH 716_ EAGVA 721_ PQPPL 726_ KEPFA 731_ SLQSP 736_ FPTDT 741_ APTTT 746_ APAVA 751_ VTTTT 756_ TTTTT 761_ TTATQ 766_ EEEKK 771_ PPPAL 776_ PPPPP 781_ LAKFP 786_ PPSQP 791_ QPPPP 796_ PPPSP 801_ ASLLK 806_ SLASV 811_ LEGQK 816_ YCYRG 821_ TGAAV 826_ STRPG 831_ PLPTT 836_ QYSPG 841_ PPSGA 846_ TALPP 851_ TSAAP 856_ SAQGS 861_ PQPSA 866_ SSSSQ 871_ FSTSG 876_ GPWAR 881_ ERRAG 886_ EEPVP 891_ GPMTP 896_ TQPPP 901_ PLSLP 906_ PARSE 911_ SEVLE 916_ EISRA 921_ CETLV 926_ ERVGR 931_ SATDP 936_ ADPVD 941_ TAEPA 946_ DSGTE 951_ RLLPP 956_ AQAKE 961_ EAGGV 966_ AAVSG 971_ SCKRR 976_ QKEHQ 981_ KEHRR 986_ HRRAC 991_ KDSVG 996_ RRPRE 1001_ GRAKA 1006_ KAKVP 1011_ KEKSR 1016_ RVLGN 1021_ LDLQS 1026_ EEIQG 1031_ REKSR 1036_ PDLGG 1041_ ASKAK 1046_ PPTAP 1051_ APPSA 1056_ PAPSA 1061_ QPTPP 1066_ SASVP 1071_ GKKAR 1076_ EEAPG 1081_ PPGVS 1086_ RADML 1091_ KLRSL 1096_ SEGPP 1101_ KELKI 1106_ RLIKV 1111_ ESGDK 1116_ ETFIA 1121_ SEVEE 1126_ RRLRM 1131_ ADLTI 1136_ SHCAA 1141_ DVVRA 1146_ SRNAK 1151_ VKGKF 1156_ RESYL 1161_ SPAQS 1166_ VKPKI 1171_ NTEEK 1176_ LPREK 1181_ LNPPT 1186_ PSIYL 1191_ ESKRD 1196_ AFSPV 1201_ LLQFC 1206_ TDPRN 1211_ PITVI 1216_ RGLAG 1221_ SLRLN 1226_ LGLFS 1231_ TKTLV 1236_ EASGE 1241_ HTVEV 1246_ RTQVQ 1251_ QPSDE 1256_ NWDLT 1261_ GTRQI 1266_ WPCES 1271_ SRSHT 1276_ TIAKY 1281_ AQYQA 1286_ SSFQE 1291_ SLQEE 1296_ KESED 1301_ EESEE 1306_ PDSTT 1311_ GTPPS 1316_ SAPDP 1321_ KNHHI 1326_ IKFGT 1331_ NIDLS 1336_ DAKRW 1341_ KPQLQ 1346_ ELLKL 1351_ PAFMR 1356_ VTSTG 1361_ NMLSH 1366_ VGHTI 1371_ LGMNT 1376_ VQLYM 1381_ KVPGS 1386_ RTPGH 1391_ QENNN 1396_ FCSVN 1401_ INIGP 1406_ GDCEW 1411_ FAVHE 1416_ HYWET 1421_ ISAFC 1426_ DRHGV 1431_ DYLTG 1436_ SWWPI 1441_ LDDLY 1446_ ASNIP 1451_ VYRFV 1456_ QRPGD 1461_ LVWIN 1466_ AGTVH 1471_ WVQAT 1476_ GWCNN 1481_ IAWNV 1486_ GPLTA 1491_ YQYQL 1496_ ALERY 1501_ EWNEV 1506_ KNVKS 1511_ IVPMI 1516_ HVSWN 1521_ VARTV 1526_ KISDP 1531_ DLFKM 1536_ IKFCL 1541_ LQSMK 1546_ HCQVQ 1551_ RESLV 1556_ RAGKK 1561_ IAYQG 1566_ RVKDE 1571_ PAYYC 1576_ NECDV 1581_ EVFNI 1586_ LFVTS 1591_ ENGSR 1596_ NTYLV 1601_ HCEGC 1606_ ARRRS 1611_ AGLQG 1616_ VVVLE 1621_ QYRTE 1626_ ELAQA 1631_ YDAFT 1636_LAPAS
1: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity)