Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein)
1_MFDCW 6_ RFILC 11_ KRPGS 16_ NSYSS 21_ PQRPN 26_ EAKKE 31_ ETDHQ 36_ IDVSD 41_ VIRLV 46_ QDTPE 51_ ATAMA 56_ TDEIM 61_ HQDIV 66_ PLCAA 71_ DIQDQ 76_ LKKRF 81_ AYLSG 86_ GRGQD 91_ GSPVI 96_ TFPDY 101_ PAFSE 106_ IPDKE 111_ FQNVM 116_ TYLTS 121_ IPSLQ 126_ DAGIG 131_ FILVI 136_ DRRRD 141_ KWTSV 146_ KASVL 151_ RIAAS 156_ FPANL 161_ QLVLV 166_ LRPTG 171_ FFQRT 176_ LSDIA 181_ FKFNR 186_ DDFKM 191_ KVPVI 196_ MLSSV 201_ PDLHG 206_ YIDKS 211_ QLTED 216_ LGGTL 221_ DYCHS 226_ RWLCQ 231_ RTAIE 236_ SFALM 241_ VKQTA 246_ QMLQS 251_ FGTEL 256_ AETEL 261_ PNDVQ 266_ STSSV 271_ LCAHT 276_ EKKDK 281_ AKEDL 286_ RLALK 291_ EGHSV 296_ LESLR 301_ ELQAE 306_ GSEPS 311_ VNQDQ 316_ LDNQA 321_ TVQRL 326_ LAQLN 331_ ETEAA 336_ FDEFW 341_ AKHQQ 346_ KLEQC 351_ LQLRH 356_ FEQGF 361_ REVKA 366_ ILDAA 371_ SQKIA 376_ TFTDI 381_ GNSLA 386_ HVEHL 391_ LRDLA 396_ SFEEK 401_ SGVAV 406_ ERARA 411_ LSLDG 416_ EQLIG 421_ NKHYA 426_ VDSIR 431_ PKCQE 436_ LRHLC 441_ DQFSA 446_ EIARR 451_ RGLLS 456_ KSLEL 461_ HRRLE 466_ TSMKW 471_ CDEGI 476_ YLLAS 481_ QPVDK 486_ CQSQD 491_ GAEAA 496_ LQEIE 501_ KFLET 506_ GAENK 511_ IQELN 516_ AIYKE 521_ YESIL 526_ NQDLM 531_ EHVRK 536_ VFQKQ 541_ ASMEE 546_ VFHRR 551_ QASLK 556_ KLAAR 561_ QTRPV 566_ QPVAP 571_ RPEAL 576_ AKSPC 581_ PSPGI 586_ RRGSE 591_ NSSSE 596_ GGALR 601_ RGPYR 606_ RAKSE 611_ MSESR 616_ QGRGS 621_ AGEEE 626_ ESLAI 631_ LRRHV 636_ MSELL 641_ DTERA 646_ YVEEL 651_ LCVLE 656_ GYAAE 661_ MDNPL 666_ MAHLL 671_ STGLH 676_ NKKDV 681_ LFGNM 686_ EEIYH 691_ FHNRI 696_ FLREL 701_ ENYTD 706_ CPELV 711_ GRCFL 716_ ERMED 721_ FQIYE 726_ KYCQN 731_ KPRSE 736_ SLWRQ 741_ CSDCP 746_ FFQEC 751_ QRKLD 756_ HKLSL 761_ DSYLL 766_ KPVQR 771_ ITKYQ 776_ LLLKE 781_ MLKYS 786_ RNCEG 791_ AEDLQ 796_ EALSS 801_ ILGIL 806_ KAVND 811_ SMHLI 816_ AITGY 821_ DGNLG 826_ DLGKL 831_ LMQGS 836_ FSVWT 841_ DHKRG 846_ HTKVK 851_ ELARF 856_ KPMQR 861_ HLFLH 866_ EKAVL 871_ FCKKR 876_ EENGE 881_ GYEKA 886_ PSYSY 891_ KQSLN 896_ MAAVG 901_ ITENV 906_ KGDAK 911_ KFEIW 916_ YNARE 921_ EVYIV 926_ QAPTP 931_ EIKAA 936_ WVNEI 941_ RKVLT 946_ SQLQA 951_ CREAS 956_ QHRAL 961_ EQSQS 966_ LPLPA 971_ PTSTS 976_ PSRGN 981_ SRNIK 986_ KLEER 991_ KTDPL 996_ SLEGY 1001_ VSSAP 1006_ LTKPP 1011_ EKGKG 1016_ WSKTS 1021_ HSLEA 1026_ PEDDG 1031_ GWSSA 1036_ EEQIN 1041_ SSDAE 1046_ EDGGL 1051_ GPKKL 1056_ VPGKY 1061_ TVVAD 1066_ HEKGG 1071_ PDALR 1076_ VRSGD 1081_ VVELV 1086_ QEGDE 1091_ GLWYV 1096_ RDPTT 1101_ GKEGW 1106_ VPASS 1111_ LSVRL 1116_ GPSGS 1121_ AQCLS 1126_ SSGKA 1131_HVPRA
1: Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669)
2: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669)