Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
1_MFRTK 6_ RSALV 11_ RRLWR 16_ SRAPG 21_ GEDEE 26_ EGAGG 31_ GGGGG 36_ ELRGE 41_ GATDS 46_ RAHGA 51_ GGGGP 56_ GRAGC 61_ CLGKA 66_ VRGAK 71_ GHHHP 76_ HPPAA 81_ GAGAA 86_ GGAEA 91_ DLKAL 96_ THSVL 101_ KKLKE 106_ RQLEL 111_ LLQAV 116_ ESRGG 121_ TRTAC 126_ LLLPG 131_ RLDCR 136_ LGPGA 141_ PAGAQ 146_ PAQPP 151_ SSYSL 156_ PLLLC 161_ KVFRW 166_ PDLRH 171_ SSEVK 176_ RLCCC 181_ ESYGK 186_ INPEL 191_ VCCNP 196_ HHLSR 201_ LCELE 206_ SPPPP 211_ YSRYP 216_ MDFLK 221_ PTADC 226_ PDAVP 231_ SSAET 236_ GGTNY 241_ LAPGG 246_ LSDSQ 251_ LLLEP 256_ GDRSH 261_ WCVVA 266_ YWEEK 271_ TRVGR 276_ LYCVQ 281_ EPSLD 286_ IFYDL 291_ PQGNG 296_ FCLGQ 301_ LNSDN 306_ KSQLV 311_ QKVRS 316_ KIGCG 321_ IQLTR 326_ EVDGV 331_ WVYNR 336_ SSYPI 341_ FIKSA 346_ TLDNP 351_ DSRTL 356_ LVHKV 361_ FPGFS 366_ IKAFD 371_ YEKAY 376_ SLQRP 381_ NDHEF 386_ MQQPW 391_ TGFTV 396_ QISFV 401_ KGWGQ 406_ CYTRQ 411_ FISSC 416_ PCWLE 421_VIFNS
1: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access (PubMed:21791611). Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator