NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein)
1_MTARG 6_ LALGL 11_ LLLLL 16_ CPAQV 21_ FSQSC 26_ VWYGE 31_ CGIAY 36_ GDKRY 41_ NCEYS 46_ GPPKP 51_ LPKDG 56_ YDLVQ 61_ ELCPG 66_ FFFGN 71_ VSLCC 76_ DVRQL 81_ QTLKD 86_ NLQLP 91_ LQFLS 96_ RCPSC 101_ FYNLL 106_ NLFCE 111_ LTCSP 116_ RQSQF 121_ LNVTA 126_ TEDYV 131_ DPVTN 136_ QTKTN 141_ VKELQ 146_ YYVGQ 151_ SFANA 156_ MYNAC 161_ RDVEA 166_ PSSND 171_ KALGL 176_ LCGKD 181_ ADACN 186_ ATNWI 191_ EYMFN 196_ KDNGQ 201_ APFTI 206_ TPVFS 211_ DFPVH 216_ GMEPM 221_ NNATK 226_ GCDES 231_ VDEVT 236_ APCSC 241_ QDCSI 246_ VCGPK 251_ PQPPP 256_ PPAPW 261_ TILGL 266_ DAMYV 271_ IMWIT 276_ YMAFL 281_ LVFFG 286_ AFFAV 291_ WCYRK 296_ RYFVS 301_ EYTPI 306_ DSNIA 311_ FSVNA 316_ SDKGE 321_ ASCCD 326_ PVSAA 331_ FEGCL 336_ RRLFT 341_ RWGSF 346_ CVRNP 351_ GCVIF 356_ FSLVF 361_ ITACS 366_ SGLVF 371_ VRVTT 376_ NPVDL 381_ WSAPS 386_ SQARL 391_ EKEYF 396_ DQHFG 401_ PFFRT 406_ EQLII 411_ RAPLT 416_ DKHIY 421_ QPYPS 426_ GADVP 431_ FGPPL 436_ DIQIL 441_ HQVLD 446_ LQIAI 451_ ENITA 456_ SYDNE 461_ TVTLQ 466_ DICLA 471_ PLSPY 476_ NTNCT 481_ ILSVL 486_ NYFQN 491_ SHSVL 496_ DHKKG 501_ DDFFV 506_ YADYH 511_ THFLY 516_ CVRAP 521_ ASLND 526_ TSLLH 531_ DPCLG 536_ TFGGP 541_ VFPWL 546_ VLGGY 551_ DDQNY 556_ NNATA 561_ LVITF 566_ PVNNY 571_ YNDTE 576_ KLQRA 581_ QAWEK 586_ EFINF 591_ VKNYK 596_ NPNLT 601_ ISFTA 606_ ERSIE 611_ DELNR 616_ ESDSD 621_ VFTVV 626_ ISYAI 631_ MFLYI 636_ SLALG 641_ HMKSC 646_ RRLLV 651_ DSKVS 656_ LGIAG 661_ ILIVL 666_ SSVAC 671_ SLGVF 676_ SYIGL 681_ PLTLI 686_ VIEVI 691_ PFLVL 696_ AVGVD 701_ NIFIL 706_ VQAYQ 711_ RDERL 716_ QGETL 721_ DQQLG 726_ RVLGE 731_ VAPSM 736_ FLSSF 741_ SETVA 746_ FFLGA 751_ LSVMP 756_ AVHTF 761_ SLFAG 766_ LAVFI 771_ DFLLQ 776_ ITCFV 781_ SLLGL 786_ DIKRQ 791_ EKNRL 796_ DIFCC 801_ VRGAE 806_ DGTSV 811_ QASES 816_ CLFRF 821_ FKNSY 826_ SPLLL 831_ KDWMR 836_ PIVIA 841_ IFVGV 846_ LSFSI 851_ AVLNK 856_ VDIGL 861_ DQSLS 866_ MPDDS 871_ YMVDY 876_ FKSIS 881_ QYLHA 886_ GPPVY 891_ FVLEE 896_ GHDYT 901_ SSKGQ 906_ NMVCG 911_ GMGCN 916_ NDSLV 921_ QQIFN 926_ AAQLD 931_ NYTRI 936_ GFAPS 941_ SWIDD 946_ YFDWV 951_ KPQSS 956_ CCRVD 961_ NITDQ 966_ FCNAS 971_ VVDPA 976_ CVRCR 981_ PLTPE 986_ GKQRP 991_ QGGDF 996_ MRFLP 1001_ MFLSD 1006_ NPNPK 1011_ CGKGG 1016_ HAAYS 1021_ SAVNI 1026_ LLGHG 1031_ TRVGA 1036_ TYFMT 1041_ YHTVL 1046_ QTSAD 1051_ FIDAL 1056_ KKARL 1061_ IASNV 1066_ TETMG 1071_ INGSA 1076_ YRVFP 1081_ YSVFY 1086_ VFYEQ 1091_ YLTII 1096_ DDTIF 1101_ NLGVS 1106_ LGAIF 1111_ LVTMV 1116_ LLGCE 1121_ LWSAV 1126_ IMCAT 1131_ IAMVL 1136_ VNMFG 1141_ VMWLW 1146_ GISLN 1151_ AVSLV 1156_ NLVMS 1161_ CGISV 1166_ EFCSH 1171_ ITRAF 1176_ TVSMK 1181_ GSRVE 1186_ RAEEA 1191_ LAHMG 1196_ SSVFS 1201_ GITLT 1206_ KFGGI 1211_ VVLAF 1216_ AKSQI 1221_ FQIFY 1226_ FRMYL 1231_ AMVLL 1236_ GATHG 1241_ LIFLP 1246_ VLLSY 1251_ IGPSV 1256_ NKAKS 1261_ CATEE 1266_ RYKGT 1271_ERERL
1: Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:10821832, PubMed:12554680, PubMed:18772377, PubMed:27238017, PubMed:9211849, PubMed:9927649). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:18772377, PubMed:19563754, PubMed:27238017, PubMed:27378690, PubMed:28784760, PubMed:9211849, PubMed:9927649). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed:19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9 (PubMed:28336668)
2: (Microbial infection) Acts as an endosomal entry receptor for ebolavirus