T-box transcription factor TBX3 (T-box protein 3)
1_MSLSM 6_ RDPVI 11_ PGTSM 16_ AYHPF 21_ LPHRA 26_ PDFAM 31_ SAVLG 36_ HQPPF 41_ FPALT 46_ LPPNG 51_ AAALS 56_ LPGAL 61_ AKPIM 66_ DQLVG 71_ AAETG 76_ IPFSS 81_ LGPQA 86_ HLRPL 91_ KTMEP 96_ EEEVE 101_ DDPKV 106_ HLEAK 111_ ELWDQ 116_ FHKRG 121_ TEMVI 126_ TKSGR 131_ RMFPP 136_ FKVRC 141_ SGLDK 146_ KAKYI 151_ LLMDI 156_ IAADD 161_ CRYKF 166_ HNSRW 171_ MVAGK 176_ ADPEM 181_ PKRMY 186_ IHPDS 191_ PATGE 196_ QWMSK 201_ VVTFH 206_ KLKLT 211_ NNISD 216_ KHGFT 221_ LAFPS 226_ DHATW 231_ QGNYS 236_ FGTQT 241_ ILNSM 246_ HKYQP 251_ RFHIV 256_ RANDI 261_ LKLPY 266_ STFRT 271_ YLFPE 276_ TEFIA 281_ VTAYQ 286_ NDKIT 291_ QLKID 296_ NNPFA 301_ KGFRD 306_ TGNGR 311_ REKRK 316_ QLTLQ 321_ SMRVF 326_ DERHK 331_ KENGT 336_ SDESS 341_ SEQAA 346_ FNCFA 351_ QASSP 356_ AASTV 361_ GTSNL 366_ KDLCP 371_ SEGES 376_ DAEAE 381_ SKEEH 386_ GPEAC 391_ DAAKI 396_ STTTS 401_ EEPCR 406_ DKGSP 411_ AVKAH 416_ LFAAE 421_ RPRDS 426_ GRLDK 431_ ASPDS 436_ RHSPA 441_ TISSS 446_ TRGLG 451_ AEERR 456_ SPVRE 461_ GTAPA 466_ KVEEA 471_ RALPG 476_ KEAFA 481_ PLTVQ 486_ TDAAA 491_ AHLAQ 496_ GPLPG 501_ LGFAP 506_ GLAGQ 511_ QFFNG 516_ HPLFL 521_ HPSQF 526_ AMGGA 531_ FSSMA 536_ AAGMG 541_ PLLAT 546_ VSGAS 551_ TGVSG 556_ LDSTA 561_ MASAA 566_ AAQGL 571_ SGASA 576_ ATLPF 581_ HLQQH 586_ VLASQ 591_ GLAMS 596_ PFGSL 601_ FPYPY 606_ TYMAA 611_ AAAAS 616_ SAAAS 621_ SSVHR 626_ HPFLN 631_ LNTMR 636_ PRLRY 641_ SPYSI 646_ PVPVP 651_ DGSSL 656_ LTTAL 661_ PSMAA 666_ AAGPL 671_ DGKVA 676_ ALAAS 681_ PASVA 686_ VDSGS 691_ ELNSR 696_ SSTLS 701_ SSSMS 706_ LSPKL 711_ CAEKE 716_ AATSE 721_ LQSIQ 726_ RLVSG 731_ LEAKP 736_DRSRS
1: Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537)