Angiopoietin-2 (ANG-2)
1_MWQIV 6_ FFTLS 11_ CDLVL 16_ AAAYN 21_ NFRKS 26_ MDSIG 31_ KKQYQ 36_ VQHGS 41_ CSYTF 46_ LLPEM 51_ DNCRS 56_ SSSPY 61_ VSNAV 66_ QRDAP 71_ LEYDD 76_ SVQRL 81_ QVLEN 86_ IMENN 91_ TQWLM 96_ KLENY 101_ IQDNM 106_ KKEMV 111_ EIQQN 116_ AVQNQ 121_ TAVMI 126_ EIGTN 131_ LLNQT 136_ AEQTR 141_ KLTDV 146_ EAQVL 151_ NQTTR 156_ LELQL 161_ LEHSL 166_ STNKL 171_ EKQIL 176_ DQTSE 181_ INKLQ 186_ DKNSF 191_ LEKKV 196_ LAMED 201_ KHIIQ 206_ LQSIK 211_ EEKDQ 216_ LQVLV 221_ SKQNS 226_ IIEEL 231_ EKKIV 236_ TATVN 241_ NSVLQ 246_ KQQHD 251_ LMETV 256_ NNLLT 261_ MMSTS 266_ NSAKD 271_ PTVAK 276_ EEQIS 281_ FRDCA 286_ EVFKS 291_ GHTTN 296_ GIYTL 301_ TFPNS 306_ TEEIK 311_ AYCDM 316_ EAGGG 321_ GWTII 326_ QRRED 331_ GSVDF 336_ QRTWK 341_ EYKVG 346_ FGNPS 351_ GEYWL 356_ GNEFV 361_ SQLTN 366_ QQRYV 371_ LKIHL 376_ KDWEG 381_ NEAYS 386_ LYEHF 391_ YLSSE 396_ ELNYR 401_ IHLKG 406_ LTGTA 411_ GKISS 416_ ISQPG 421_ NDFST 426_ KDGDN 431_ DKCIC 436_ KCSQM 441_ LTGGW 446_ WFDAC 451_ GPSNL 456_ NGMYY 461_ PQRQN 466_ TNKFN 471_ GIKWY 476_ YWKGS 481_ GYSLK 486_ ATTMM 491_IRPAD
1: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Involved in the regulation of lymphangiogenesis (PubMed:32908006)