Importin subunit alpha-6 (Karyopherin subunit alpha-5)
1_MDAMA 6_ SPGKD 11_ NYRMK 16_ SYKNK 21_ ALNPQ 26_ EMRRR 31_ REEEG 36_ IQLRK 41_ QKREE 46_ QLFKR 51_ RNVYL 56_ PRNDE 61_ SMLES 66_ PIQDP 71_ DISST 76_ VPIPE 81_ EEVVT 86_ TDMVQ 91_ MIFSN 96_ NADQQ 101_ LTATQ 106_ KFRKL 111_ LSKEP 116_ NPPID 121_ QVIQK 126_ PGVVQ 131_ RFVKF 136_ LERNE 141_ NCTLQ 146_ FEAAW 151_ ALTNI 156_ ASGTF 161_ LHTKV 166_ VIETG 171_ AVPIF 176_ IKLLN 181_ SEHED 186_ VQEQA 191_ VWALG 196_ NIAGD 201_ NAECR 206_ DFVLN 211_ CEILP 216_ PLLEL 221_ LTNSN 226_ RLTTT 231_ RNAVW 236_ ALSNL 241_ CRGKN 246_ PPPNF 251_ SKVSP 256_ CLNVL 261_ SRLLF 266_ SSDPD 271_ VLADV 276_ CWALS 281_ YLSDG 286_ PNDKI 291_ QAVID 296_ SGVCR 301_ RLVEL 306_ LMHND 311_ YKVVS 316_ PALRA 321_ VGNIV 326_ TGDDI 331_ QTQVI 336_ LNCSA 341_ LPCLL 346_ HLLSS 351_ PKESI 356_ RKEAC 361_ WTVSN 366_ ITAGN 371_ RAQIQ 376_ AVIDA 381_ NIFPV 386_ LIEIL 391_ QKAEF 396_ RTRKE 401_ AAWAI 406_ TNATS 411_ GGTPE 416_ QIRYL 421_ VALGC 426_ IKPLC 431_ DLLTV 436_ MDSKI 441_ VQVAL 446_ NGLEN 451_ ILRLG 456_ EQESK 461_ QNGIG 466_ INPYC 471_ ALIEE 476_ AYGLD 481_ KIEFL 486_ QSHEN 491_ QEIYQ 496_ KAFDL 501_ IEHYF 506_ GVEED 511_ DPSIV 516_ PQVDE 521_ NQQQF 526_ IFQQQ 531_EAPMD
1: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS