Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)
1_MILLE 6_ VNNRI 11_ IEETL 16_ ALKFE 21_ NAAAG 26_ NKPEA 31_ VEVTF 36_ ADFDG 41_ VLYHI 46_ SNPNG 51_ DKTKV 56_ MVSIS 61_ LKFYK 66_ ELQAH 71_ GADEL 76_ LKRVY 81_ GSFLV 86_ NPESG 91_ YNVSL 96_ LYDLE 101_ NLPAS 106_ KDSIV 111_ HQAGM 116_ LKRNC 121_ FASVF 126_ EKYFQ 131_ FQEEG 136_ KEGEN 141_ RAVIH 146_ YRDDE 151_ TMYVE 156_ SKKDR 161_ VTVVF 166_ STVFK 171_ DDDDV 176_ VIGKV 181_ FMQEF 186_ KEGRR 191_ ASHTA 196_ PQVLF 201_ SHREP 206_ PLELK 211_ DTDAA 216_ VGDNI 221_ GYITF 226_ VLFPR 231_ HTNAS 236_ ARDNT 241_ INLIH 246_ TFRDY 251_ LHYHI 256_ KCSKA 261_ YIHTR 266_ MRAKT 271_ SDFLK 276_ VLNRA 281_ RPDAE 286_ KKEMK 291_TITGK
1: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)