Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
1_MPAYH 6_ SSLMD 11_ PDTKL 16_ IGNMA 21_ LLPIR 26_ SQFKG 31_ PAPRE 36_ TKDTD 41_ IVDEA 46_ IYYFK 51_ ANVFF 56_ KNYEI 61_ KNEAD 66_ RTLIY 71_ ITLYI 76_ SECLK 81_ KLQKC 86_ NSKSQ 91_ GEKEM 96_ YTLGI 101_ TNFPI 106_ PGEPG 111_ FPLNA 116_ IYAKP 121_ ANKQE 126_ DEVMR 131_ AYLQQ 136_ LRQET 141_ GLRLC 146_ EKVFD 151_ PQNDK 156_ PSKWW 161_ TCFVK 166_ RQFMN 171_KSLSG
1: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)