Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)
1_MRELV 6_ NIPLV 11_ HILTL 16_ VAFSG 21_ TEKLP 26_ KAPVI 31_ TTPLE 36_ TVDAL 41_ VEEVA 46_ TFMCA 51_ VESYP 56_ QPEIS 61_ WTRNK 66_ ILIKL 71_ FDTRY 76_ SIREN 81_ GQLLT 86_ ILSVE 91_ DSDDG 96_ IYCCT 101_ ANNGV 106_ GGAVE 111_ SCGAL 116_ QVKMK 121_ PKITR 126_ PPINV 131_ KIIEG 136_ LKAVL 141_ PCTTM 146_ GNPKP 151_ SVSWI 156_ KGDSP 161_ LRENS 166_ RIAVL 171_ ESGSL 176_ RIHNV 181_ QKEDA 186_ GQYRC 191_ VAKNS 196_ LGTAY 201_ SKVVK 206_ LEVEV 211_ FARIL 216_ RAPES 221_ HNVTF 226_ GSFVT 231_ LHCTA 236_ TGIPV 241_ PTITW 246_ IENGN 251_ AVSSG 256_ SIQES 261_ VKDRV 266_ IDSRL 271_ QLFIT 276_ KPGLY 281_ TCIAT 286_ NKHGE 291_ KFSTA 296_ KAAAT 301_ ISIAE 306_ WSKPQ 311_ KDNKG 316_ YCAQY 321_ RGEVC 326_ NAVLA 331_ KDALV 336_ FLNTS 341_ YADPE 346_ EAQEL 351_ LVHTA 356_ WNELK 361_ VVSPV 366_ CRPAA 371_ EALLC 376_ NHIFQ 381_ ECSPG 386_ VVPTP 391_ IPICR 396_ EYCLA 401_ VKELF 406_ CAKEW 411_ LVMEE 416_ KTHRG 421_ LYRSE 426_ MHLLS 431_ VPECS 436_ KLPSM 441_ HWDPT 446_ ACARL 451_ PHLDY 456_ NKENL 461_ KTFPP 466_ MTSSK 471_ PSVDI 476_ PNLPS 481_ SSSSS 486_ FSVSP 491_ TYSMT 496_ VIISI 501_ MSSFA 506_ IFVLL 511_ TITTL 516_ YCCRR 521_ RKQWK 526_ NKKRE 531_ SAAVT 536_ LTTLP 541_ SELLL 546_ DRLHP 551_ NPMYQ 556_ RMPLL 561_ LNPKL 566_ LSLEY 571_ PRNNI 576_ EYVRD 581_ IGEGA 586_ FGRVF 591_ QARAP 596_ GLLPY 601_ EPFTM 606_ VAVKM 611_ LKEEA 616_ SADMQ 621_ ADFQR 626_ EAALM 631_ AEFDN 636_ PNIVK 641_ LLGVC 646_ AVGKP 651_ MCLLF 656_ EYMAY 661_ GDLNE 666_ FLRSM 671_ SPHTV 676_ CSLSH 681_ SDLSM 686_ RAQVS 691_ SPGPP 696_ PLSCA 701_ EQLCI 706_ ARQVA 711_ AGMAY 716_ LSERK 721_ FVHRD 726_ LATRN 731_ CLVGE 736_ NMVVK 741_ IADFG 746_ LSRNI 751_ YSADY 756_ YKANE 761_ NDAIP 766_ IRWMP 771_ PESIF 776_ YNRYT 781_ TESDV 786_ WAYGV 791_ VLWEI 796_ FSYGL 801_ QPYYG 806_ MAHEE 811_ VIYYV 816_ RDGNI 821_ LSCPE 826_ NCPVE 831_ LYNLM 836_ RLCWS 841_ KLPAD 846_ RPSFT 851_ SIHRI 856_ LERMC 861_ERAEG
1: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity)