Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK)
1_MGSPE 6_ DDLIG 11_ IPFPD 16_ HSSEL 21_ LSCLN 26_ EQRQL 31_ GHLCD 36_ LTIRT 41_ QGLEY 46_ RTHRA 51_ VLAAC 56_ SHYFK 61_ KLFTE 66_ GGGGA 71_ VMGAG 76_ GSGTA 81_ TGGAG 86_ AGVCE 91_ LDFVG 96_ PEALG 101_ ALLEF 106_ AYTAT 111_ LTTSS 116_ ANMPA 121_ VLQAA 126_ RLLEI 131_ PCVIA 136_ ACMEI 141_ LQGSG 146_ LEAPS 151_ PDEDD 156_ CERAR 161_ QYLEA 166_ FATAT 171_ ASGVP 176_ NGEDS 181_ PPQVP 186_ LPPPP 191_ PPPPR 196_ PVARR 201_ SRKPR 206_ KAFLQ 211_ TKGAR 216_ ANHLV 221_ PEVPT 226_ VPAHP 231_ LTYEE 236_ EEVAG 241_ RVGSS 246_ GGSGP 251_ GDSYS 256_ PPTGT 261_ ASPPE 266_ GPQSY 271_ EPYEG 276_ EEEEE 281_ ELVYP 286_ PAYGL 291_ AQGGG 296_ PPLSP 301_ EELGS 306_ DEDAI 311_ DPDLM 316_ AYLSS 321_ LHQDN 326_ LAPGL 331_ DSQDK 336_ LVRKR 341_ RSQMP 346_ QECPV 351_ CHKII 356_ HGAGK 361_ LPRHM 366_ RTHTG 371_ EKPFA 376_ CEVCG 381_ VRFTR 386_ NDKLK 391_ IHMRK 396_ HTGER 401_ PYSCP 406_ HCPAR 411_ FLHSY 416_ DLKNH 421_ MHLHT 426_ GDRPY 431_ ECHLC 436_ HKAFA 441_ KEDHL 446_ QRHLK 451_ GQNCL 456_ EVRTR 461_ RRRKD 466_ DAPPH 471_ YPPPS 476_ TAAAS 481_ PAGLD 486_ LSNGH 491_ LDTFR 496_ LSLAR 501_ FWEQS 506_ APTGP 511_ PVSTP 516_ GPPDD 521_ DEEEG 526_ APTTP 531_QAEGA
1: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity)