Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)
1_MEVAV 6_ EKAVA 11_ AAAAA 16_ SAAAS 21_ GGPSA 26_ APSGE 31_ NEAES 36_ RQGPD 41_ SERGG 46_ EAARL 51_ NLLDT 56_ CAVCH 61_ QNIQS 66_ RAPKL 71_ LPCLH 76_ SFCQR 81_ CLPAP 86_ QRYLM 91_ LPAPM 96_ LGSAE 101_ TPPPV 106_ PAPGS 111_ PVSGS 116_ SPFAT 121_ QVGVI 126_ RCPVC 131_ SQECA 136_ ERHII 141_ DNFFV 146_ KDTTE 151_ VPSST 156_ VEKSN 161_ QVCTS 166_ CEDNA 171_ EANGF 176_ CVECV 181_ EWLCK 186_ TCIRA 191_ HQRVK 196_ FTKDH 201_ TVRQK 206_ EEVSP 211_ EAVGV 216_ TSQRP 221_ VFCPF 226_ HKKEQ 231_ LKLYC 236_ ETCDK 241_ LTCRD 246_ CQLLE 251_ HKEHR 256_ YQFIE 261_ EAFQN 266_ QKVII 271_ DTLIT 276_ KLMEK 281_ TKYIK 286_ FTGNQ 291_ IQNRI 296_ IEVNQ 301_ NQKQV 306_ EQDIK 311_ VAIFT 316_ LMVEI 321_ NKKGK 326_ ALLHQ 331_ LESLA 336_ KDHRM 341_ KLMQQ 346_ QQEVA 351_ GLSKQ 356_ LEHVM 361_ HFSKW 366_ AVSSG 371_ SSTAL 376_ LYSKR 381_ LITYR 386_ LRHLL 391_ RARCD 396_ ASPVT 401_ NNTIQ 406_ FHCDP 411_ SFWAQ 416_ NIINL 421_ GSLVI 426_ EDKES 431_ QPQMP 436_ KQNPV 441_ VEQNS 446_ QPPSG 451_ LSSNQ 456_ LSKFP 461_ TQISL 466_ AQLRL 471_ QHMQQ 476_ QVMAQ 481_ RQQVQ 486_ RRPAP 491_ VGLPN 496_ PRMQG 501_ PIQQP 506_ SISHQ 511_ QPPPR 516_ LINFQ 521_ NHSPK 526_ PNGPV 531_ LPPHP 536_ QQLRY 541_ PPNQN 546_ IPRQA 551_ IKPNP 556_ LQMAF 561_ LAQQA 566_ IKQWQ 571_ ISSGQ 576_ GTPST 581_ TNSTS 586_ STPSS 591_ PTITS 596_ AAGYD 601_ GKAFG 606_ SPMID 611_ LSSPV 616_ GGSYN 621_ LPSLP 626_ DIDCS 631_ STIML 636_ DNIVR 641_ KDTNI 646_ DHGQP 651_ RPPSN 656_ RTVQS 661_ PNSSV 666_ PSPGL 671_ AGPVT 676_ MTSVH 681_ PPIRS 686_ PSASS 691_ VGSRG 696_ SSGSS 701_ SKPAG 706_ ADSTH 711_ KVPVV 716_ MLEPI 721_ RIKQE 726_ NSGPP 731_ ENYDF 736_ PVVIV 741_ KQESD 746_ EESRP 751_ QNANY 756_ PRSIL 761_ TSLLL 766_ NSSQS 771_ STSEE 776_ TVLRS 781_ DAPDS 786_ TGDQP 791_ GLHQD 796_ NSSNG 801_ KSEWL 806_ DPSQK 811_ SPLHV 816_ GETRK 821_ EDDPN 826_ EDWCA 831_ VCQNG 836_ GELLC 841_ CEKCP 846_ KVFHL 851_ SCHVP 856_ TLTNF 861_ PSGEW 866_ ICTFC 871_ RDLSK 876_ PEVEY 881_ DCDAP 886_ SHNSE 891_ KKKTE 896_ GLVKL 901_ TPIDK 906_ RKCER 911_ LLLFL 916_ YCHEM 921_ SLAFQ 926_ DPVPL 931_ TVPDY 936_ YKIIK 941_ NPMDL 946_ STIKK 951_ RLQED 956_ YSMYS 961_ KPEDF 966_ VADFR 971_ LIFQN 976_ CAEFN 981_ EPDSE 986_ VANAG 991_ IKLEN 996_ YFEEL 1001_ LKNLY 1006_ PEKRF 1011_ PKPEF 1016_ RNESE 1021_ DNKFS 1026_ DDSDD 1031_ DFVQP 1036_ RKKRL 1041_KSIEE
1: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611)