Low-density lipoprotein receptor class A domain-containing protein 4
1_MPEAG 6_ FQATN 11_ AFTEC 16_ KFTCT 21_ SGKCL 26_ YLGSL 31_ VCNQQ 36_ NDCGD 41_ NSDEE 46_ NCLLV 51_ TEHPP 56_ PGIFN 61_ SELEF 66_ AQIII 71_ IVVVV 76_ TVMVV 81_ VIVCL 86_ LNHYK 91_ VSTRS 96_ FINRP 101_ NQSRR 106_ REDGL 111_ PQEGC 116_ LWPSD 121_ SAAPR 126_ LGASE 131_ IMHAP 136_ RSRDR 141_ FTAPS 146_ FIQRD 151_ RFSRF 156_ QPTYP 161_ YVQHE 166_ IDLPP 171_ TISLS 176_ DGEEP 181_ PPYQG 186_ PCTLQ 191_ LRDPE 196_ QQMEL 201_ NRESV 206_ RAPPN 211_ RTIFD 216_ SDLID 221_ IAMYS 226_ GGPCP 231_ PSSNS 236_ GISAS 241_ TCSSN 246_ GRMEG 251_ PPPTY 256_ SEVMG 261_ HHPGA 266_ SFLHH 271_ QRSNA 276_ HRGSR 281_ LQFQQ 286_ NNAES 291_ TIVPI 296_ KGKDR 301_KPGNL
1: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal