Axin-1 (Axis inhibition protein 1) (hAxin)
1_MNIQE 6_ QGFPL 11_ DLGAS 16_ FTEDA 21_ PRPPV 26_ PGEEG 31_ ELVST 36_ DPRPA 41_ SYSFC 46_ SGKGV 51_ GIKGE 56_ TSTAT 61_ PRRSD 66_ LDLGY 71_ EPEGS 76_ ASPTP 81_ PYLKW 86_ AESLH 91_ SLLDD 96_ QDGIS 101_ LFRTF 106_ LKQEG 111_ CADLL 116_ DFWFA 121_ CTGFR 126_ KLEPC 131_ DSNEE 136_ KRLKL 141_ ARAIY 146_ RKYIL 151_ DNNGI 156_ VSRQT 161_ KPATK 166_ SFIKG 171_ CIMKQ 176_ LIDPA 181_ MFDQA 186_ QTEIQ 191_ ATMEE 196_ NTYPS 201_ FLKSD 206_ IYLEY 211_ TRTGS 216_ ESPKV 221_ CSDQS 226_ SGSGT 231_ GKGIS 236_ GYLPT 241_ LNEDE 246_ EWKCD 251_ QDMDE 256_ DDGRD 261_ AAPPG 266_ RLPQK 271_ LLLET 276_ AAPRV 281_ SSSRR 286_ YSEGR 291_ EFRYG 296_ SWREP 301_ VNPYY 306_ VNAGY 311_ ALAPA 316_ TSAND 321_ SEQQS 326_ LSSDA 331_ DTLSL 336_ TDSSV 341_ DGIPP 346_ YRIRK 351_ QHRRE 356_ MQESV 361_ QVNGR 366_ VPLPH 371_ IPRTY 376_ RVPKE 381_ VRVEP 386_ QKFAE 391_ ELIHR 396_ LEAVQ 401_ RTREA 406_ EEKLE 411_ ERLKR 416_ VRMEE 421_ EGEDG 426_ DPSSG 431_ PPGPC 436_ HKLPP 441_ APAWH 446_ HFPPR 451_ CVDMG 456_ CAGLR 461_ DAHEE 466_ NPESI 471_ LDEHV 476_ QRVLR 481_ TPGRQ 486_ SPGPG 491_ HRSPD 496_ SGHVA 501_ KMPVA 506_ LGGAA 511_ SGHGK 516_ HVPKS 521_ GAKLD 526_ AAGLH 531_ HHRHV 536_ HHHVH 541_ HSTAR 546_ PKEQV 551_ EAEAT 556_ RRAQS 561_ SFAWG 566_ LEPHS 571_ HGARS 576_ RGYSE 581_ SVGAA 586_ PNASD 591_ GLAHS 596_ GKVGV 601_ ACKRN 606_ AKKAE 611_ SGKSA 616_ STEVP 621_ GASED 626_ AEKNQ 631_ KIMQW 636_ IIEGE 641_ KEISR 646_ HRRTG 651_ HGSSG 656_ TRKPQ 661_ PHENS 666_ RPLSL 671_ EHPWA 676_ GPQLR 681_ TSVQP 686_ SHLFI 691_ QDPTM 696_ PPHPA 701_ PNPLT 706_ QLEEA 711_ RRRLE 716_ EEEKR 721_ ASRAP 726_ SKQRY 731_ VQEVM 736_ RRGRA 741_ CVRPA 746_ CAPVL 751_ HVVPA 756_ VSDME 761_ LSETE 766_ TRSQR 771_ KVGGG 776_ SAQPC 781_ DSIVV 786_ AYYFC 791_ GEPIP 796_ YRTLV 801_ RGRAV 806_ TLGQF 811_ KELLT 816_ KKGSY 821_ RYYFK 826_ KVSDE 831_ FDCGV 836_ VFEEV 841_ REDEA 846_ VLPVF 851_ EEKII 856_GKVEK
1: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684)