Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)
1_MAAGD 6_ GDVKL 11_ GTLGS 16_ GSESS 21_ NDGGS 26_ ESPGD 31_ AGAAA 36_ EGGGW 41_ AAAAL 46_ ALLTG 51_ GGEML 56_ LNVAL 61_ VALVL 66_ LGAYR 71_ LWVRW 76_ GRRGL 81_ GAGAG 86_ AGEES 91_ PATSL 96_ PRMKK 101_ RDFSL 106_ EQLRQ 111_ YDGSR 116_ NPRIL 121_ LAVNG 126_ KVFDV 131_ TKGSK 136_ FYGPA 141_ GPYGI 146_ FAGRD 151_ ASRGL 156_ ATFCL 161_ DKDAL 166_ RDEYD 171_ DLSDL 176_ NAVQM 181_ ESVRE 186_ WEMQF 191_ KEKYD 196_ YVGRL 201_ LKPGE 206_ EPSEY 211_ TDEED 216_TKDHN
1: Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity)