CTD small phosphatase-like protein (CTDSP-like) (EC 3.1.3.16) (Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3) (NIF-like protein) (Nuclear LIM interactor-interacting factor 1) (NLI-interacting factor 1) (Protein YA22) (hYA22) (RBSP3) (Small C-terminal domain phosphatase 3) (SCP3) (Small CTD phosphatase 3)
1_MDGPA 6_ IITQV 11_ TNPKE 16_ DEGRL 21_ PGAGE 26_ KASQC 31_ NVSLK 36_ KQRSR 41_ SILSS 46_ FFCCF 51_ RDYNV 56_ EAPPP 61_ SSPSV 66_ LPPLV 71_ EENGG 76_ LQKGD 81_ QRQVI 86_ PIPSP 91_ PAKYL 96_ LPEVT 101_ VLDYG 106_ KKCVV 111_ IDLDE 116_ TLVHS 121_ SFKPI 126_ SNADF 131_ IVPVE 136_ IDGTI 141_ HQVYV 146_ LKRPH 151_ VDEFL 156_ QRMGQ 161_ LFECV 166_ LFTAS 171_ LAKYA 176_ DPVAD 181_ LLDRW 186_ GVFRA 191_ RLFRE 196_ SCVFH 201_ RGNYV 206_ KDLSR 211_ LGREL 216_ SKVII 221_ VDNSP 226_ ASYIF 231_ HPENA 236_ VPVQS 241_ WFDDM 246_ TDTEL 251_ LDLIP 256_ FFEGL 261_ SREDD 266_ VYSML 271_HRLCN
1: Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation