NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4)
1_MEKIL 6_ QMAEG 11_ IDIGE 16_ MPSYD 21_ LVLSK 26_ PSKGQ 31_ KRHLS 36_ TCDGQ 41_ NPPKK 46_ QAGSK 51_ FHARP 56_ RFEPV 61_ HFVAS 66_ SSKDE 71_ RQEDP 76_ YGPQT 81_ KEVNE 86_ QTHFA 91_ SMPRD 96_ IYQDY 101_ TQDSF 106_ SIQDG 111_ NSQYC 116_ DSSGF 121_ ILTKD 126_ QPVTA 131_ NMYFD 136_ SGNPA 141_ PSTTS 146_ QQANS 151_ QSTPE 156_ PSPSQ 161_ TFPES 166_ VVAEK 171_ QYFIE 176_ KLTAT 181_ IWKNL 186_ SNPEM 191_ TSGSD 196_ KINYT 201_ YMLTR 206_ CIQAC 211_ KTNPE 216_ YIYAP 221_ LKEIP 226_ PADIP 231_ KNKKL 236_ LTDGY 241_ ACEVR 246_ CQNIY 251_ LTTGY 256_ AGSKN 261_ GSRDR 266_ ATELA 271_ VKLLQ 276_ KRIEV 281_ RVVRR 286_ KFKHT 291_ FGEDL 296_ VVCQI 301_ GMSSY 306_ EFPPA 311_ LKPPE 316_ DLVVL 321_ GKDAS 326_ GQPIF 331_ NASAK 336_ HWTNF 341_ VITEN 346_ ANDAI 351_ GILNN 356_ SASFN 361_ KMSIE 366_ YKYEM 371_ MPNRT 376_ WRCRV 381_ FLQDH 386_ CLAEG 391_ YGTKK 396_ TSKHA 401_ AADEA 406_ LKILQ 411_ KTQPT 416_ YPSVK 421_ SSQCH 426_ TGSSP 431_ RGSGK 436_ KKDIK 441_ DLVVY 446_ ENSSN 451_ PVCTL 456_ NDTAQ 461_ FNRMT 466_ VEYVY 471_ ERMTG 476_ LRWKC 481_ KVILE 486_ SEVIA 491_ EAVGV 496_ KKTVK 501_ YEAAG 506_ EAVKT 511_ LKKTQ 516_ PTVIN 521_ NLKKG 526_ AVEDV 531_ ISRNE 536_ IQGRS 541_ AEEAY 546_ KQQIK 551_ EDNIG 556_ NQLLR 561_ KMGWT 566_ GGGLG 571_ KSGEG 576_ IREPI 581_ SVKEQ 586_ HKREG 591_ LGLDV 596_ ERVNK 601_ IAKRD 606_ IEQII 611_ RNYAR 616_ SESHT 621_ DLTFS 626_ RELTN 631_ DERKQ 636_ IHQIA 641_ QKYGL 646_ KSKSH 651_ GVGHD 656_ RYLVV 661_ GRKRR 666_ KEDLL 671_ DQLKQ 676_ EGQVG 681_HYELV
1: Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553)