Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase)
1_MDSSV 6_ IQRKK 11_ VAVIG 16_ GGLVG 21_ SLQAC 26_ FLAKR 31_ NFQID 36_ VYEAR 41_ EDTRV 46_ ATFTR 51_ GRSIN 56_ LALSH 61_ RGRQA 66_ LKAVG 71_ LEDQI 76_ VSQGI 81_ PMRAR 86_ MIHSL 91_ SGKKS 96_ AIPYG 101_ TKSQY 106_ ILSVS 111_ RENLN 116_ KDLLT 121_ AAEKY 126_ PNVKM 131_ HFNHR 136_ LLKCN 141_ PEEGM 146_ ITVLG 151_ SDKVP 156_ KDVTC 161_ DLIVG 166_ CDGAY 171_ STVRS 176_ HLMKK 181_ PRFDY 186_ SQQYI 191_ PHGYM 196_ ELTIP 201_ PKNGD 206_ YAMEP 211_ NYLHI 216_ WPRNT 221_ FMMIA 226_ LPNMN 231_ KSFTC 236_ TLFMP 241_ FEEFE 246_ KLLTS 251_ NDVVD 256_ FFQKY 261_ FPDAI 266_ PLIGE 271_ KLLVQ 276_ DFFLL 281_ PAQPM 286_ ISVKC 291_ SSFHF 296_ KSHCV 301_ LLGDA 306_ AHAIV 311_ PFFGQ 316_ GMNAG 321_ FEDCL 326_ VFDEL 331_ MDKFS 336_ NDLSL 341_ CLPVF 346_ SRLRI 351_ PDDHA 356_ ISDLS 361_ MYNYI 366_ EMRAH 371_ VNSSW 376_ FIFQK 381_ NMERF 386_ LHAIM 391_ PSTFI 396_ PLYTM 401_ VTFSR 406_ IRYHE 411_ AVQRW 416_ HWQKK 421_ VINKG 426_ LFFLG 431_ SLIAI 436_ SSTYL 441_ LIHYM 446_ SPRSF 451_ LRLRR 456_ PWNWI 461_ AHFRN 466_ TTCFP 471_ AKAVD 476_ SLEQI 481_SNLIS
1: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702, PubMed:29429898). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable)