Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)
1_MADRR 6_ RQRAS 11_ QDTED 16_ EESGA 21_ SGSDS 26_ GGSPL 31_ RGGGS 36_ CSGSA 41_ GGGGS 46_ GSLPS 51_ QRGGR 56_ TGALH 61_ LRRVE 66_ SGGAK 71_ SAEES 76_ ECESE 81_ DGIEG 86_ DAVLS 91_ DYESA 96_ EDSEG 101_ EEGEY 106_ SEEEN 111_ SKVEL 116_ KSEAN 121_ DAVNS 126_ STKEE 131_ KGEEK 136_ PDTKS 141_ TVTGE 146_ RQSGD 151_ GQEST 156_ EPVEN 161_ KVGKK 166_ GPKHL 171_ DDDED 176_ RKNPA 181_ YIPRK 186_ GLFFE 191_ HDLRG 196_ QTQEE 201_ EVRPK 206_ GRQRK 211_ LWKDE 216_ GRWEH 221_ DKFRE 226_ DEQAP 231_ KSRQE 236_ LIALY 241_ GYDIR 246_ SAHNP 251_ DDIKP 256_ RRIRK 261_ PRYGS 266_ PPQRD 271_ PNWNG 276_ ERLNK 281_ SHRHQ 286_ GLGGT 291_ LPPRT 296_ FINRN 301_ AAGTG 306_ RMSAP 311_ RNYSR 316_ SGGFK 321_ EGRAG 326_ FRPVE 331_ AGGQH 336_ GGRSG 341_ ETVKH 346_ EISYR 351_ SRRLE 356_ QTSVR 361_ DPSPE 366_ ADAPV 371_ LGSPE 376_ KEEAA 381_ SEPPA 386_ AAPDA 391_ APPPP 396_ DRPIE 401_ KKSYS 406_ RARRT 411_ RTKVG 416_ DAVKL 421_ AEEVP 426_ PPPEG 431_ LIPAP 436_ PVPET 441_ TPTPP 446_ TKTGT 451_ WEAPV 456_ DSSTS 461_ GLEQD 466_ VAQLN 471_ IAEQN 476_ WSPGQ 481_ PSFLQ 486_ PRELR 491_ GMPNH 496_ IHMGA 501_ GPPPQ 506_ FNRME 511_ EMGVQ 516_ GGRAK 521_ RYSSQ 526_ RQRPV 531_ PEPPA 536_ PPVHI 541_ SIMEG 546_ HYYDP 551_ LQFQG 556_ PIYTH 561_ GDSPA 566_ PLPPQ 571_ GMLVQ 576_ PGMNL 581_ PHPGL 586_ HPHQT 591_ PAPLP 596_ NPGLY 601_ PPPVS 606_ MSPGQ 611_ PPPQQ 616_ LLAPT 621_ YFSAP 626_ GVMNF 631_ GNPSY 636_ PYAPG 641_ ALPPP 646_ PPPHL 651_ YPNTQ 656_ APSQV 661_ YGGVT 666_ YYNPA 671_ QQQVQ 676_ PKPSP 681_ PRRTP 686_ QPVTI 691_ KPPPP 696_EVVSR
1: Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer