Leptin receptor gene-related protein (Endospanin-1) (Leptin receptor overlapping transcript protein) (OB-R gene-related protein) (OB-RGRP)
1_MAGVK 6_ ALVAL 11_ SFSGA 16_ IGLTF 21_ LMLGC 26_ ALEDY 31_ GVYWP 36_ LFVLI 41_ FHAIS 46_ PIPHF 51_ IAKRV 56_ TYDSD 61_ ATSSA 66_ CRELA 71_ YFFTT 76_ GIVVS 81_ AFGFP 86_ VILAR 91_ VAVIK 96_ WGACG 101_ LVLAG 106_ NAVIF 111_ LTIQG 116_ FFLIF 121_ GRGDD 126_FSWEQ
1: Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability