Chloride intracellular channel protein 2 (XAP121)
1_MSGLR 6_ PGTQV 11_ DPEIE 16_ LFVKA 21_ GSDGE 26_ SIGNC 31_ PFCQR 36_ LFMIL 41_ WLKGV 46_ KFNVT 51_ TVDMT 56_ RKPEE 61_ LKDLA 66_ PGTNP 71_ PFLVY 76_ NKELK 81_ TDFIK 86_ IEEFL 91_ EQTLA 96_ PPRYP 101_ HLSPK 106_ YKESF 111_ DVGCN 116_ LFAKF 121_ SAYIK 126_ NTQKE 131_ ANKNF 136_ EKSLL 141_ KEFKR 146_ LDDYL 151_ NTPLL 156_ DEIDP 161_ DSAEE 166_ PPVSR 171_ RLFLD 176_ GDQLT 181_ LADCS 186_ LLPKL 191_ NIIKV 196_ AAKKY 201_ RDFDI 206_ PAEFS 211_ GVWRY 216_ LHNAY 221_ AREEF 226_ THTCP 231_ EDKEI 236_ ENTYA 241_NVAKQ
1: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Displays weak glutathione peroxidase activity (Probable) (PubMed:25581026). Can insert into membranes and form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Modulates the activity of RYR2 and inhibits calcium influx