Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
1_MSLIR 6_ KKGFY 11_ KQDVN 16_ KTAWE 21_ LPKTY 26_ VSPTH 31_ VGSGA 36_ YGSVC 41_ SAIDK 46_ RSGEK 51_ VAIKK 56_ LSRPF 61_ QSEIF 66_ AKRAY 71_ RELLL 76_ LKHMQ 81_ HENVI 86_ GLLDV 91_ FTPAS 96_ SLRNF 101_ YDFYL 106_ VMPFM 111_ QTDLQ 116_ KIMGM 121_ EFSEE 126_ KIQYL 131_ VYQML 136_ KGLKY 141_ IHSAG 146_ VVHRD 151_ LKPGN 156_ LAVNE 161_ DCELK 166_ ILDFG 171_ LARHA 176_ DAEMT 181_ GYVVT 186_ RWYRA 191_ PEVIL 196_ SWMHY 201_ NQTVD 206_ IWSVG 211_ CIMAE 216_ MLTGK 221_ TLFKG 226_ KDYLD 231_ QLTQI 236_ LKVTG 241_ VPGTE 246_ FVQKL 251_ NDKAA 256_ KSYIQ 261_ SLPQT 266_ PRKDF 271_ TQLFP 276_ RASPQ 281_ AADLL 286_ EKMLE 291_ LDVDK 296_ RLTAA 301_ QALTH 306_ PFFEP 311_ FRDPE 316_ EETEA 321_ QQPFD 326_ DSLEH 331_ EKLTV 336_ DEWKQ 341_ HIYKE 346_ IVNFS 351_ PIARK 356_DSRRR
1: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells