Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)
1_MATAT 6_ EQWVL 11_ VEMVQ 16_ ALYEA 21_ PAYHL 26_ ILEGI 31_ LILWI 36_ IRLLF 41_ SKTYK 46_ LQERS 51_ DLTVK 56_ EKEEL 61_ IEEWQ 66_ PEPLV 71_ PPVPK 76_ DHPAL 81_ NYNIV 86_ SGPPS 91_ HKTVV 96_ NGKEC 101_ INFAS 106_ FNFLG 111_ LLDNP 116_ RVKAA 121_ ALASL 126_ KKYGV 131_ GTCGP 136_ RGFYG 141_ TFDVH 146_ LDLED 151_ RLAKF 156_ MKTEE 161_ AIIYS 166_ YGFAT 171_ IASAI 176_ PAYSK 181_ RGDIV 186_ FVDRA 191_ ACFAI 196_ QKGLQ 201_ ASRSD 206_ IKLFK 211_ HNDMA 216_ DLERL 221_ LKEQE 226_ IEDQK 231_ NPRKA 236_ RVTRR 241_ FIVVE 246_ GLYMN 251_ TGTIC 256_ PLPEL 261_ VKLKY 266_ KYKAR 271_ IFLEE 276_ SLSFG 281_ VLGEH 286_ GRGVT 291_ EHYGI 296_ NIDDI 301_ DLISA 306_ NMENA 311_ LASIG 316_ GFCCG 321_ RSFVI 326_ DHQRL 331_ SGQGY 336_ CFSAS 341_ LPPLL 346_ AAAAI 351_ EALNI 356_ MEENP 361_ GIFAV 366_ LKEKC 371_ GQIHK 376_ ALQGI 381_ SGLKV 386_ VGESL 391_ SPAFH 396_ LQLEE 401_ STGSR 406_ EQDVR 411_ LLQEI 416_ VDQCM 421_ NRSIA 426_ LTQAR 431_ YLEKE 436_ EKCLP 441_ PPSIR 446_ VVVTV 451_ EQTEE 456_ ELERA 461_ ASTIK 466_EVAQA
1: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core (PubMed:19416851, PubMed:33558762, PubMed:36170811). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851, PubMed:33558762). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19416851, PubMed:19648650). The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851, PubMed:19648650, PubMed:33558761, PubMed:33558762). Required for adipocyte cell viability and metabolic homeostasis (By similarity)