Polyunsaturated fatty acid lipoxygenase ALOX15B (15-lipoxygenase 2) (15-LOX-2) (Arachidonate 15-lipoxygenase B) (15-LOX-B) (EC 1.13.11.33) (Arachidonate 15-lipoxygenase type II) (Linoleate 13-lipoxygenase 15-LOb) (EC 1.13.11.-)
1_MAEFR 6_ VRVST 11_ GEAFG 16_ AGTWD 21_ KVSVS 26_ IVGTR 31_ GESPP 36_ LPLDN 41_ LGKEF 46_ TAGAE 51_ EDFQV 56_ TLPED 61_ VGRVL 66_ LLRVH 71_ KAPPV 76_ LPLLG 81_ PLAPD 86_ AWFCR 91_ WFQLT 96_ PPRGG 101_ HLLFP 106_ CYQWL 111_ EGAGT 116_ LVLQE 121_ GTAKV 126_ SWADH 131_ HPVLQ 136_ QQRQE 141_ ELQAR 146_ QEMYQ 151_ WKAYN 156_ PGWPH 161_ CLDEK 166_ TVEDL 171_ ELNIK 176_ YSTAK 181_ NANFY 186_ LQAGS 191_ AFAEM 196_ KIKGL 201_ LDRKG 206_ LWRSL 211_ NEMKR 216_ IFNFR 221_ RTPAA 226_ EHAFE 231_ HWQED 236_ AFFAS 241_ QFLNG 246_ LNPVL 251_ IRRCH 256_ YLPKN 261_ FPVTD 266_ AMVAS 271_ VLGPG 276_ TSLQA 281_ ELEKG 286_ SLFLV 291_ DHGIL 296_ SGIQT 301_ NVING 306_ KPQFS 311_ AAPMT 316_ LLYQS 321_ PGCGP 326_ LLPLA 331_ IQLSQ 336_ TPGPN 341_ SPIFL 346_ PTDDK 351_ WDWLL 356_ AKTWV 361_ RNAEF 366_ SFHEA 371_ LTHLL 376_ HSHLL 381_ PEVFT 386_ LATLR 391_ QLPHC 396_ HPLFK 401_ LLIPH 406_ TRYTL 411_ HINTL 416_ ARELL 421_ IVPGQ 426_ VVDRS 431_ TGIGI 436_ EGFSE 441_ LIQRN 446_ MKQLN 451_ YSLLC 456_ LPEDI 461_ RTRGV 466_ EDIPG 471_ YYYRD 476_ DGMQI 481_ WGAVE 486_ RFVSE 491_ IIGIY 496_ YPSDE 501_ SVQDD 506_ RELQA 511_ WVREI 516_ FSKGF 521_ LNQES 526_ SGIPS 531_ SLETR 536_ EALVQ 541_ YVTMV 546_ IFTCS 551_ AKHAA 556_ VSAGQ 561_ FDSCA 566_ WMPNL 571_ PPSMQ 576_ LPPPT 581_ SKGLA 586_ TCEGF 591_ IATLP 596_ PVNAT 601_ CDVIL 606_ ALWLL 611_ SKEPG 616_ DQRPL 621_ GTYPD 626_ EHFTE 631_ EAPRR 636_ SIATF 641_ QSRLA 646_ QISRG 651_ IQERN 656_ QGLVL 661_ PYTYL 666_ DPPLI 671_ENSVS
1: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (Probable) (PubMed:10542053, PubMed:10625675, PubMed:12704195, PubMed:17493578, PubMed:18311922, PubMed:24282679, PubMed:24497644, PubMed:32404334, PubMed:9177185). It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (Probable) (PubMed:10625675, PubMed:11956198, PubMed:12704195, PubMed:17493578, PubMed:24282679, PubMed:24497644, PubMed:9177185). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (Probable) (PubMed:10542053, PubMed:27435673). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist (PubMed:11956198, PubMed:17493578, PubMed:18311922). Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates (PubMed:27145229). Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively down-regulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids (PubMed:27435673). Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation (PubMed:11839751, PubMed:12704195). May also regulate cytokine secretion by macrophages and therefore play a role in the immune response (PubMed:18067895). May also regulate macrophage differentiation into proatherogenic foam cells (PubMed:22912809)
2: Does not convert arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE