Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)
1_MAGLY 6_ SLGVS 11_ VFSDQ 16_ GGRKY 21_ MEDVT 26_ QIVVE 31_ PEPTA 36_ EEKPS 41_ PRRSL 46_ SQPLP 51_ PRPSP 56_ AALPG 61_ GEVSG 66_ KGPAV 71_ AAREA 76_ RDPLP 81_ DAGAS 86_ PAPSR 91_ CCRRR 96_ SSVAF 101_ FAVCD 106_ GHGGR 111_ EAAQF 116_ AREHL 121_ WGFIK 126_ KQKGF 131_ TSSEP 136_ AKVCA 141_ AIRKG 146_ FLACH 151_ LAMWK 156_ KLAEW 161_ PKTMT 166_ GLPST 171_ SGTTA 176_ SVVII 181_ RGMKM 186_ YVAHV 191_ GDSGV 196_ VLGIQ 201_ DDPKD 206_ DFVRA 211_ VEVTQ 216_ DHKPE 221_ LPKER 226_ ERIEG 231_ LGGSV 236_ MNKSG 241_ VNRVV 246_ WKRPR 251_ LTHNG 256_ PVRRS 261_ TVIDQ 266_ IPFLA 271_ VARAL 276_ GDLWS 281_ YDFFS 286_ GEFVV 291_ SPEPD 296_ TSVHT 301_ LDPQK 306_ HKYII 311_ LGSDG 316_ LWNMI 321_ PPQDA 326_ ISMCQ 331_ DQEEK 336_ KYLMG 341_ EHGQS 346_ CAKML 351_ VNRAL 356_ GRWRQ 361_ RMLRA 366_ DNTSA 371_ IVICI 376_ SPEVD 381_ NQGNF 386_ TNEDE 391_ LYLNL 396_ TDSPS 401_ YNSQE 406_ TCVMT 411_ PSPCS 416_ TPPVK 421_ SLEED 426_ PWPRV 431_ NSKDH 436_ IPALV 441_ RSNAF 446_ SENFL 451_ EVSAE 456_ IAREN 461_ VQGVV 466_ IPSKD 471_ PEPLE 476_ ENCAK 481_ ALTLR 486_ IHDSL 491_ NNSLP 496_ IGLVP 501_ TNSTN 506_ TVMDQ 511_ KNLKM 516_ STPGQ 521_ MKAQE 526_ IERTP 531_ PTNFK 536_ RTLEE 541_ SNSGP 546_ LMKKH 551_ RRNGL 556_ SRSSG 561_ AQPAS 566_ LPTTS 571_ QRKNS 576_ VKLTM 581_ RRRLR 586_ GQKKI 591_ GNPLL 596_HQHRK
1: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity)