DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1)
1_MGSKK 6_ LKRVG 11_ LSQEL 16_ CDRLS 21_ RHQIL 26_ TCQDF 31_ LCLSP 36_ LELMK 41_ VTGLS 46_ YRGVH 51_ ELLCM 56_ VSRAC 61_ APKMQ 66_ TAYGI 71_ KAQRS 76_ ADFSP 81_ AFLST 86_ TLSAL 91_ DEALH 96_ GGVAC 101_ GSLTE 106_ ITGPP 111_ GCGKT 116_ QFCIM 121_ MSILA 126_ TLPTN 131_ MGGLE 136_ GAVVY 141_ IDTES 146_ AFSAE 151_ RLVEI 156_ AESRF 161_ PRYFN 166_ TEEKL 171_ LLTSS 176_ KVHLY 181_ RELTC 186_ DEVLQ 191_ RIESL 196_ EEEII 201_ SKGIK 206_ LVILD 211_ SVASV 216_ VRKEF 221_ DAQLQ 226_ GNLKE 231_ RNKFL 236_ AREAS 241_ SLKYL 246_ AEEFS 251_ IPVIL 256_ TNQIT 261_ THLSG 266_ ALASQ 271_ ADLVS 276_ PADDL 281_ SLSEG 286_ TSGSS 291_ CVIAA 296_ LGNTW 301_ SHSVN 306_ TRLIL 311_ QYLDS 316_ ERRQI 321_ LIAKS 326_ PLAPF 331_ TSFVY 336_ TIKEE 341_ GLVLQ 346_ ETTFC 351_ SVTQA 356_ ELNWA 361_ PEILP 366_ PQPPE 371_ QLGLQ 376_MCHHT
1: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway