Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66)
1_MEIKE 6_ EGASE 11_ EGQHF 16_ LPTAQ 21_ ANDPG 26_ DCQFT 31_ SIQKT 36_ PNEPQ 41_ LEFIL 46_ ACKDL 51_ VAPVR 56_ DRKLN 61_ TLVQI 66_ SVIHP 71_ VEQSL 76_ TRYSS 81_ TEIVE 86_ GTRDP 91_ LFLTG 96_ VTFPS 101_ EYPIY 106_ EETKI 111_ KLTVY 116_ DVKDK 121_ SHDTV 126_ RTSVL 131_ PEHKD 136_ PPPEV 141_ GRSFL 146_ GYASF 151_ KVGEL 156_ LKSKE 161_ QLLVL 166_ SLRTS 171_ DGGKV 176_ VGTIE 181_ VSVVK 186_ MGEIE 191_ DGEAD 196_ HITTD 201_ VQGQK 206_ CALVC 211_ ECTAP 216_ ESVSG 221_ KDNLP 226_ FLNSV 231_ LKNPV 236_ CKLYR 241_ FPTSD 246_ NKWMR 251_ IREQM 256_ SESIL 261_ SFHIP 266_ KELIS 271_ LHIKE 276_ DLCRN 281_ QEIKE 286_ LGELS 291_ PHWDN 296_ LRKNV 301_ LTHCD 306_ QMVNM 311_ YQDIL 316_ TELSK 321_ ETGSS 326_ FKSSS 331_ SKGEK 336_ TLEFV 341_ PINLH 346_ LQRMQ 351_ VHSPH 356_ LKDAL 361_ YDVIT 366_ VGAPA 371_ AHFQG 376_ FKNGG 381_ LRKLL 386_ HRFET 391_ ERRNT 396_ GYQFI 401_ YYSPE 406_ NTAKA 411_ KEVLS 416_ NINQL 421_ QPLIA 426_ THADL 431_ LLNSA 436_ SQHSP 441_ DSLKN 446_ SLKML 451_ SEKTE 456_ LFVHA 461_ FKDQL 466_ VRSAL 471_ LALYT 476_ ARPGG 481_ ILKKP 486_ PSPKS 491_ STEES 496_ SPQDQ 501_ PPVMR 506_ GQDSI 511_ PHHSD 516_ YDEEE 521_ WDRVW 526_ ANVGK 531_ SLNCI 536_ IAMVD 541_ KLIER 546_ DGGSE 551_ GSGGN 556_ NDGEK 561_ EPSLT 566_ DAIPS 571_ HPRED 576_ WYEQL 581_ YPLIL 586_ TLKDC 591_ MGEVV 596_ NRAKQ 601_ SLTFV 606_ LLQEL 611_ AYSLP 616_ QCLML 621_ TLRRD 626_ IVFSQ 631_ ALAGL 636_ VCGFI 641_ IKLQT 646_ SLYDP 651_ GFLQQ 656_ LHTVG 661_ LIVQY 666_ EGLLS 671_ TYSDE 676_ IGMLE 681_ DMAVG 686_ ISDLK 691_ KVAFK 696_ IIEAK 701_ SNDVL 706_ PVITG 711_ RREHY 716_ VVEVK 721_ LPARM 726_ FESLP 731_ LQIKE 736_ GQLLH 741_ VYPVL 746_ FNVGI 751_ NEQQT 756_ LAERF 761_ GDVSL 766_ QESIN 771_ QENFE 776_ LLQEY 781_ YKIFM 786_ EKMPP 791_ DYISH 796_ FQEQN 801_ DLKAL 806_ LENLL 811_ QNIQS 816_ KKRKN 821_ VEIMW 826_ LAATI 831_ CRKLN 836_ GIRFT 841_ CCKSA 846_ KDRTS 851_ MSVTL 856_ EQCSI 861_ LRDEH 866_ QLHKD 871_ FFIRA 876_ LDCMR 881_ REGCR 886_ IENVL 891_ KNIKC 896_ RKYAF 901_ NMLQL 906_ MAFPK 911_ YYRPP 916_EGTYG
1: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612)