E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)
1_METLE 6_ SELTC 11_ PICLE 16_ LFEDP 21_ LLLPC 26_ AHSLC 31_ FNCAH 36_ RILVS 41_ HCATN 46_ ESVES 51_ ITAFQ 56_ CPTCR 61_ HVITL 66_ SQRGL 71_ DGLKR 76_ NVTLQ 81_ NIIDR 86_ FQKAS 91_ VSGPN 96_ SPSET 101_ RRERA 106_ FDANT 111_ MTSAE 116_ KVLCQ 121_ FCDQD 126_ PAQDA 131_ VKTCV 136_ TCEVS 141_ YCDEC 146_ LKATH 151_ PNKKP 156_ FTGHR 161_ LIEPI 166_ PDSHI 171_ RGLMC 176_ LEHED 181_ EKVNM 186_ YCVTD 191_ DQLIC 196_ ALCKL 201_ VGRHR 206_ DHQVA 211_ ALSER 216_ YDKLK 221_ QNLES 226_ NLTNL 231_ IKRNT 236_ ELETL 241_ LAKLI 246_ QTCQH 251_ VEVNA 256_ SRQEA 261_ KLTEE 266_ CDLLI 271_ EIIQQ 276_ RRQII 281_ GTKIK 286_ EGKVM 291_ RLRKL 296_ AQQIA 301_ NCKQC 306_ IERSA 311_ SLISQ 316_ AEHSL 321_ KENDH 326_ ARFLQ 331_ TAKNI 336_ TERVS 341_ MATAS 346_ SQVLI 351_ PEINL 356_ NDTFD 361_ TFALD 366_ FSREK 371_ KLLEC 376_ LDYLT 381_ APNPP 386_ TIREE 391_ LCTAS 396_ YDTIT 401_ VHWTS 406_ DDEFS 411_ VVSYE 416_ LQYTI 421_ FTGQA 426_ NVVSL 431_ CNSAD 436_ SWMIV 441_ PNIKQ 446_ NHYTV 451_ HGLQS 456_ GTKYI 461_ FMVKA 466_ INQAG 471_ SRSSE 476_ PGKLK 481_ TNSQP 486_ FKLDP 491_ KSAHR 496_ KLKVS 501_ HDNLT 506_ VERDE 511_ SSSKK 516_ SHTPE 521_ RFTSQ 526_ GSYGV 531_ AGNVF 536_ IDSGR 541_ HYWEV 546_ VISGS 551_ TWYAI 556_ GLAYK 561_ SAPKH 566_ EWIGK 571_ NSASW 576_ ALCRC 581_ NNNWV 586_ VRHNS 591_ KEIPI 596_ EPAPH 601_ LRRVG 606_ ILLDY 611_ DNGSI 616_ AFYDA 621_ LNSIH 626_ LYTFD 631_ VAFAQ 636_ PVCPT 641_ FTVWN 646_ KCLTI 651_ ITGLP 656_ IPDHL 661_DCTEQ
1: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination