High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4)
1_MAKGD 6_ PKKPK 11_ GKMSA 16_ YAFFV 21_ QTCRE 26_ EHKKK 31_ NPEVP 36_ VNFAE 41_ FSKKC 46_ SERWK 51_ TMSGK 56_ EKSKF 61_ DEMAK 66_ ADKVR 71_ YDREM 76_ KDYGP 81_ AKGGK 86_ KKKDP 91_ NAPKR 96_ PPSGF 101_ FLFCS 106_ EFRPK 111_ IKSTN 116_ PGISI 121_ GDVAK 126_ KLGEM 131_ WNNLN 136_ DSEKQ 141_ PYITK 146_ AAKLK 151_ EKYEK 156_ DVADY 161_ KSKGK 166_ FDGAK 171_ GPAKV 176_ ARKKV 181_ EEEDE 186_ EEEEE 191_EEEEE
1: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity)