Forkhead box protein N1 (Winged-helix transcription factor nude)
1_MVSLP 6_ PPQSD 11_ VTLPG 16_ PTRLE 21_ GERQG 26_ DLMQA 31_ PGLPG 36_ SPAPQ 41_ SKHAG 46_ FSCSS 51_ FVSDG 56_ PPERT 61_ PSLPP 66_ HSPRI 71_ ASPGP 76_ EQVQG 81_ HCPAG 86_ PGPGP 91_ FRLSP 96_ SDKYP 101_ GFGFE 106_ EAAAS 111_ SPGRF 116_ LKGSH 121_ APFHP 126_ YKRPF 131_ HEDVF 136_ PEAET 141_ TLALK 146_ GHSFK 151_ TPGPL 156_ EAFEE 161_ IPVDV 166_ AEAEA 171_ FLPGF 176_ SAEAW 181_ CNGLP 186_ YPSQE 191_ HGPQV 196_ LGSEV 201_ KVKPP 206_ VLESG 211_ AGMFC 216_ YQPPL 221_ QHMYC 226_ SSQPP 231_ FHQYS 236_ PGGGS 241_ YPIPY 246_ LGSSH 251_ YQYQR 256_ MAPQA 261_ STDGH 266_ QPLFP 271_ KPIYS 276_ YSILI 281_ FMALK 286_ NSKTG 291_ SLPVS 296_ EIYNF 301_ MTEHF 306_ PYFKT 311_ APDGW 316_ KNSVR 321_ HNLSL 326_ NKCFE 331_ KVENK 336_ SGSSS 341_ RKGCL 346_ WALNP 351_ AKIDK 356_ MQEEL 361_ QKWKR 366_ KDPIA 371_ VRKSM 376_ AKPEE 381_ LDSLI 386_ GDKRE 391_ KLGSP 396_ LLGCP 401_ PPGLS 406_ GSGPI 411_ RPLAP 416_ PAGLS 421_ PPLHS 426_ LHPAP 431_ GPIPG 436_ KNPLQ 441_ DLLMG 446_ HTPSC 451_ YGQTY 456_ LHLSP 461_ GLAPP 466_ GPPQP 471_ LFPQP 476_ DGHLE 481_ LRAQP 486_ GTPQD 491_ SPLPA 496_ HTPPS 501_ HSAKL 506_ LAEPS 511_ PARTM 516_ HDTLL 521_ PDGDL 526_ GTDLD 531_ AINPS 536_ LTDFD 541_ FQGNL 546_ WEQLK 551_ DDSLA 556_ LDPLV 561_ LVTSS 566_ PTSSS 571_ MPPPQ 576_ PPPHC 581_ FPPGP 586_ CLTET 591_ GSGAG 596_ DLAAP 601_ GSGGS 606_ GALGD 611_ LHLTT 616_ LYSAF 621_ MELEP 626_ TPPTA 631_ PAGPS 636_ VYLSP 641_SSKPV
1: Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891)