Prosaposin receptor GPR37 (Endothelin B receptor-like protein 1) (ETBR-LP-1) (G-protein coupled receptor 37) (Parkin-associated endothelin receptor-like receptor) (PAELR)
1_MRAPG 6_ ALLAR 11_ MSRLL 16_ LLLLL 21_ KVSAS 26_ SALGV 31_ APASR 36_ NETCL 41_ GESCA 46_ PTVIQ 51_ RRGRD 56_ AWGPG 61_ NSARD 66_ VLRAR 71_ APREE 76_ QGAAF 81_ LAGPS 86_ WDLPA 91_ APGRD 96_ PAAGR 101_ GAEAS 106_ AAGPP 111_ GPPTR 116_ PPGPW 121_ RWKGA 126_ RGQEP 131_ SETLG 136_ RGNPT 141_ ALQLF 146_ LQISE 151_ EEEKG 156_ PRGAG 161_ ISGRS 166_ QEQSV 171_ KTVPG 176_ ASDLF 181_ YWPRR 186_ AGKLQ 191_ GSHHK 196_ PLSKT 201_ ANGLA 206_ GHEGW 211_ TIALP 216_ GRALA 221_ QNGSL 226_ GEGIH 231_ EPGGP 236_ RRGNS 241_ TNRRV 246_ RLKNP 251_ FYPLT 256_ QESYG 261_ AYAVM 266_ CLSVV 271_ IFGTG 276_ IIGNL 281_ AVMCI 286_ VCHNY 291_ YMRSI 296_ SNSLL 301_ ANLAF 306_ WDFLI 311_ IFFCL 316_ PLVIF 321_ HELTK 326_ KWLLE 331_ DFSCK 336_ IVPYI 341_ EVASL 346_ GVTTF 351_ TLCAL 356_ CIDRF 361_ RAATN 366_ VQMYY 371_ EMIEN 376_ CSSTT 381_ AKLAV 386_ IWVGA 391_ LLLAL 396_ PEVVL 401_ RQLSK 406_ EDLGF 411_ SGRAP 416_ AERCI 421_ IKISP 426_ DLPDT 431_ IYVLA 436_ LTYDS 441_ ARLWW 446_ YFGCY 451_ FCLPT 456_ LFTIT 461_ CSLVT 466_ ARKIR 471_ KAEKA 476_ CTRGN 481_ KRQIQ 486_ LESQM 491_ NCTVV 496_ ALTIL 501_ YGFCI 506_ IPENI 511_ CNIVT 516_ AYMAT 521_ GVSQQ 526_ TMDLL 531_ NIISQ 536_ FLLFF 541_ KSCVT 546_ PVLLF 551_ CLCKP 556_ FSRAF 561_ MECCC 566_ CCCEE 571_ CIQKS 576_ STVTS 581_ DDNDN 586_ EYTTE 591_ LELSP 596_ FSTIR 601_ REMST 606_FASVG
1: G-protein-coupled receptor that plays a role in several physiological pathways such as resolution of inflammatory pain and oligodendrocyte differentiation (By similarity). Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (PubMed:11439185, PubMed:23690594). Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination. Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway. Therefore, regulates the stability of myelin or resistance of myelin itself to demyelination. Upon activation by neuroprotectin D1 (NPD1), promotes the activation of phagocytosis in macrophages as well as the shift in cytokine release toward an anti-inflammatory profile, and thus helps to reverse inflammatory pain. In addition, the increased macrophage phagocytosis mediates protection against sepsis upon pathogen infection. Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1-dependent signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation (By similarity). May also act as a maturation factor of LRP6, protecting LRP6 from the endoplasmic reticulum (ER)-associated protein degradation (ERAD) and thereby promoting the Wnt/beta-catenin signaling pathway (PubMed:28341812)