Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)
1_MASAC 6_ GAPGP 11_ GGALG 16_ SQAPS 21_ WYHRD 26_ LSRAA 31_ AEELL 36_ ARAGR 41_ DGSFL 46_ VRDSE 51_ SVAGA 56_ FALCV 61_ LYQKH 66_ VHTYR 71_ ILPDG 76_ EDFLA 81_ VQTSQ 86_ GVPVR 91_ RFQTL 96_ GELIG 101_ LYAQP 106_ NQGLV 111_ CALLL 116_ PVEGE 121_ REPDP 126_ PDDRD 131_ ASDGE 136_ DEKPP 141_ LPPRS 146_ GSTSI 151_ SAPTG 156_ PSSPL 161_ PAPET 166_ PTAPA 171_ AESAP 176_ NGLST 181_ VSHDY 186_ LKGSY 191_ GLDLE 196_ AVRGG 201_ ASHLP 206_ HLTRT 211_ LATSC 216_ RRLHS 221_ EVDKV 226_ LSGLE 231_ ILSKV 236_ FDQQS 241_ SPMVT 246_ RLLQQ 251_ QNLPQ 256_ TGEQE 261_ LESLV 266_ LKLSV 271_ LKDFL 276_ SGIQK 281_ KALKA 286_ LQDMS 291_ STAPP 296_ APQPS 301_ TRKAK 306_ TIPVQ 311_ AFEVK 316_ LDVTL 321_ GDLTK 326_ IGKSQ 331_ KFTLS 336_ VDVEG 341_ GRLVL 346_ LRRQR 351_ DSQED 356_ WTTFT 361_ HDRIR 366_ QLIKS 371_ QRVQN 376_ KLGVV 381_ FEKEK 386_ DRTQR 391_ KDFIF 396_ VSARK 401_ REAFC 406_ QLLQL 411_ MKNKH 416_ SKQDE 421_ PDMIS 426_ VFIGT 431_ WNMGS 436_ VPPPK 441_ NVTSW 446_ FTSKG 451_ LGKTL 456_ DEVTV 461_ TIPHD 466_ IYVFG 471_ TQENS 476_ VGDRE 481_ WLDLL 486_ RGGLK 491_ ELTDL 496_ DYRPI 501_ AMQSL 506_ WNIKV 511_ AVLVK 516_ PEHEN 521_ RISHV 526_ STSSV 531_ KTGIA 536_ NTLGN 541_ KGAVG 546_ VSFMF 551_ NGTSF 556_ GFVNC 561_ HLTSG 566_ NEKTA 571_ RRNQN 576_ YLDIL 581_ RLLSL 586_ GDRQL 591_ NAFDI 596_ SLRFT 601_ HLFWF 606_ GDLNY 611_ RLDMD 616_ IQEIL 621_ NYISR 626_ KEFEP 631_ LLRVD 636_ QLNLE 641_ REKHK 646_ VFLRF 651_ SEEEI 656_ SFPPT 661_ YRYER 666_ GSRDT 671_ YAWHK 676_ QKPTG 681_ VRTNV 686_ PSWCD 691_ RILWK 696_ SYPET 701_ HIICN 706_ SYGCT 711_ DDIVT 716_ SDHSP 721_ VFGTF 726_ EVGVT 731_ SQFIS 736_ KKGLS 741_ KTSDQ 746_ AYIEF 751_ ESIEA 756_ IVKTA 761_ SRTKF 766_ FIEFY 771_ STCLE 776_ EYKKS 781_ FENDA 786_ QSSDN 791_ INFLK 796_ VQWSS 801_ RQLPT 806_ LKPIL 811_ ADIEY 816_ LQDQH 821_ LLLTV 826_ KSMDG 831_ YESYG 836_ ECVVA 841_ LKSMI 846_ GSTAQ 851_ QFLTF 856_ LSHRG 861_ EETGN 866_ IRGSM 871_ KVRVP 876_ TERLG 881_ TRERL 886_ YEWIS 891_ IDKDE 896_ AGAKS 901_ KAPSV 906_ SRGSQ 911_ EPRSG 916_ SRKPA 921_ FTEAS 926_ CPLSR 931_ LFEEP 936_ EKPPP 941_ TGRPP 946_ APPRA 951_ APREE 956_ PLTPR 961_ LKPEG 966_ APEPE 971_ GVAAP 976_ PPKNS 981_ FNNPA 986_ YYVLE 991_ GVPHQ 996_ LLPPE 1001_ PPSPA 1006_ RAPVP 1011_ SATKN 1016_ KVAIT 1021_ VPAPQ 1026_ LGHHR 1031_ HPRVG 1036_ EGSSS 1041_ DEESG 1046_ GTLPP 1051_ PDFPP 1056_ PPLPD 1061_ SAIFL 1066_ PPSLD 1071_ PLPGP 1076_ VVRGR 1081_ GGAEA 1086_ RGPPP 1091_ PKAHP 1096_ RPPLP 1101_ PGPSP 1106_ ASTFL 1111_ GEVAS 1116_ GDDRS 1121_ CSVLQ 1126_ MAKTL 1131_ SEVDY 1136_ APAGP 1141_ ARSAL 1146_ LPGPL 1151_ ELQPP 1156_ RGLPS 1161_ DYGRP 1166_ LSFPP 1171_ PRIRE 1176_ SIQED 1181_ LAEEA 1186_ PCLQG 1191_ GRASG 1196_ LGEAG 1201_ MSAWL 1206_ RAIGL 1211_ ERYEE 1216_ GLVHN 1221_ GWDDL 1226_ EFLSD 1231_ ITEED 1236_ LEEAG 1241_ VQDPA 1246_ HKRLL 1251_LDTLQ
1: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569)