Transcription factor SOX-12 (Protein SOX-22)
1_MVQQR 6_ GARAK 11_ RDGGP 16_ PPPGP 21_ GPAEE 26_ GAREP 31_ GWCKT 36_ PSGHI 41_ KRPMN 46_ AFMVW 51_ SQHER 56_ RKIMD 61_ QWPDM 66_ HNAEI 71_ SKRLG 76_ RRWQL 81_ LQDSE 86_ KIPFV 91_ REAER 96_ LRLKH 101_ MADYP 106_ DYKYR 111_ PRKKS 116_ KGAPA 121_ KARPR 126_ PPGGS 131_ GGGSR 136_ LKPGP 141_ QLPGR 146_ GGRRA 151_ AGGPL 156_ GGGAA 161_ APEDD 166_ DEDDD 171_ EELLE 176_ VRLVE 181_ TPGRE 186_ LWRMV 191_ PAGRA 196_ ARGQA 201_ ERAQG 206_ PSGEG 211_ AAAAA 216_ AASPT 221_ PSEDE 226_ EPEEE 231_ EEEAA 236_ AAEEG 241_ EEETV 246_ ASGEE 251_ SLGFL 256_ SRLPP 261_ GPAGL 266_ DCSAL 271_ DRDPD 276_ LQPPS 281_ GTSHF 286_ EFPDY 291_ CTPEV 296_ TEMIA 301_ GDWRP 306_SSIAD
1: Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3' (By similarity). Acts as a transcriptional activator (By similarity). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions (By similarity). Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation (By similarity). Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity)